Nitric oxide ages you faster and calcifies your pineal gland.

Nitric oxide is a free radical, Its toxic to our mitochondria and has the ability to block oxidative metabolism and increase inflammation.

While it has some beneficial effects in vasodilation and cGMP signaling, its production must remain structured.

In 1998, McCann published the "Nitric oxide hypothesis of aging", where he details the harmful actions of nitric oxide.

COX AND LOX

"NO activates cyclooxygenase(cox) and lipoxygenase(lox), leading to the production of physiologically relevant quantities of prostaglandin E2 (PGE2 ) and leuko trienes. In the case of iNOS, the massive release of NO, PGE2 , and leukotrienes produces toxic effects. Systemic injection of LPS causes induction of interleukin (IL)-1 mRNA followed by IL-synthesis that induces iNOS mRNA with a latency of two and four hours"

The Cox and Lox enzymes are major players in the inflammatory cascade, they responsible for around 80% of the total production of the inflammatory mediators: Prostaaglandins, Leukotriens and thromboxanes.

CRH and Cortisol

The first step in The Hypothalamic-Pituitary-Adrenal Axis is the release of CRH by the Hypothalamus, Nitric Oxide stimulates his release partly through its effect on the COX enzyme.

CRH is a toxic and very inflammatory hormone, known to be involved in IBS and Cron's disease, known to activate mast cells to release histamine and serotonin, Increases Nitric Oxide,NF-kB,PGE2. Involved in leaky gut by Increasing Vascular Permeability. High levels of CRH are found in joints of patients with rheumatoid arthritis, osteoarthritis and Hypothyroid, it acts on the Pituitary gland to secret Adrenocorticotropic Hormone (ACTH) a 39 amino acids peptide into the bloodstream, ACTH itself is also toxic, inflammatory and catabolic. In brain cells ACTH triggers excitotoxicity by increasing glutamate and lowering ATP, In the gut it activates mast cells and increases gut permeability, allowing Endotoxin (LPS) to enter the blood and cause inflammation and stress.

The Adrenal Glands secrete Cortisol and Aldosterone in response to ACTH. Cortisol is the main stress hormone in the body, It's main rule is to shred any tissue that has amino acids so that the liver can convert them to glucose. Considering that our muscles and all of our organs including the brain, liver, and thymes contain amino acids and express the Glucocorticoid receptor it becomes obvious that raising cortisol is very dangerous and should avoided.

Nitric Oxide and Infection

NO play crucial rule in killing foreign pathogens, Endotoxins are one of the main causes for inflammation in our body and they stimulate NO release, which helps to neutralize them but also acts as local signal for systemic inflammation and the production of inflammatory mediators.

Pineal Gland Calcification

Increased NO levels in the pineal, inhibits energy production and contribute to excitation, characterized with increased influx of calcium ions into the tissue which blocks melatonin production.

Nitric oxide and neurons death

Neurodegenerative diseases are characterized with increased neurons death, neuron production is very limited so when lose a neuron you lose it.

Antioxidants to protect from NO

Vitamin E + C are powerful protectors against NO.

Vitamin E: there are 4 tocopherols, gamma and delta tocopherols are much more effective in blocking Reactive Nitrogen Species, than alpha and beta.
Most products have only alpha tocopherol, I use a formula that is gamma and delta dominant.

Vitamin C: Acerola cherries/ acerola powder are the best ways to get vitamin C, Ascorbic acid is potentially dangerous and contains heavy metals and other toxic byproducts.

Aspirin: by blocking COX and LOX, lowers NO production, improves blood flow, can be a great tool to block the effects of NO.