Ray Peat: Cascara, energy, cancer and the FDA's laxative abuse

Emodin as respiratory quinone and antitumor adaptogen

1. Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agentMed Res Rev · 2007 · PMID 17019678
2. Anti-cancer properties of anthraquinones from rhubarbMed Res Rev · 2007 · PMID 17022020
3. Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodinCancer Res · 1995 · PMID 7543819
4. Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodinOncogene · 1996 · PMID 8637714
5. Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxelClin Cancer Res · 1999 · PMID 10037184
6. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growthCancer Res · 2005 · PMID 15781642
7. Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathwayCell Mol Life Sci · 2005 · PMID 15928809
8. Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylationEur J Pharmacol · 2006 · PMID 17056031
9. Anti-angiogenic effects of rhubarb and its anthraquinone derivativesJ Ethnopharmacol · 2009 · PMID 19061946
10. Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cellsInt J Oncol · 2005 · PMID 16077936

Mitochondria, ischemia, inflammation, fibrosis

1. Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: single versus multiple doses and gender differenceLife Sci · 2005 · PMID 15964600
2. Effect of anthraquinone derivatives on lipid peroxidation in rat heart mitochondria: structure-activity relationshipJ Nat Prod · 1995 · PMID 7494143
3. Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardiumLife Sci · 2007 · PMID 17939930
4. Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophagesInt J Mol Med · 2005 · PMID 15942676
5. Inducible nitric oxide synthase inhibitors of Chinese herbs III. Rheum palmatumPlanta Med · 2002 · PMID 12391547
6. Effect of emodin on pancreatic fibrosis in ratsWorld J Gastroenterol · 2007 · PMID 17230605
7. [Effects of emodin on hepatic fibrosis in rats]Zhonghua Gan Zang Bing Za Zhi · 2001 · PMID 11602058

Bowel edema, lymphatics, permeability

1. Intestinal edema decreases intestinal contractile activity via decreased myosin light chain phosphorylationCrit Care Med · 2006 · PMID 16915113
2. Contractile activity of lymphatic vessels is altered in the TNBS model of guinea pig ileitisAm J Physiol Gastrointest Liver Physiol · 2006 · PMID 16675748
3. Mast cell degranulation alters lymphatic contractile activity through action of histamineMicrocirculation · 2006 · PMID 16627364

More references from this article

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