Ray Peat on Cancer
Short answer: Ray Peat approached cancer as a metabolic and systemic disease, not as the work of one mutant cell. He wrote about the respiratory defect described by Otto Warburg, the roles of estrogen, lactic acid and polyunsaturated fat, and protective factors such as progesterone, aspirin and carbon dioxide.
What Ray Peat wrote about cancer
He criticized the doctrine of the mutant cell, which leads to the idea that only something that kills cancer cells can cure cancer. Source: Preventing and treating cancer with progesterone
He went back to Otto Warburg, who showed in the 1920s that a respiratory defect, with cells making lactic acid even when oxygen is present, is a basic feature of cancer. Peat's interest was in what causes that defect. Source: Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
He wrote that lactate itself produces signals that promote growth, and he set carbon dioxide against lactate as the other approach to cancer. Source: Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
He named radiation, estrogen and a range of chemical pollutants as the major known causes of breast cancer. Source: Breast Cancer
He described research from the 1930s onward, in primates as well as rodents, showing estrogen as carcinogenic and progesterone as protective. Source: Preventing and treating cancer with progesterone
He stressed removing polyunsaturated fats, which he wrote takes years to clear from the tissues, and noted that aspirin and salicylic acid block many of their carcinogenic effects. Source: Preventing and treating cancer with progesterone
He treated the tissue around a tumor as part of the disease. Collagen becomes more abundant and stiffer with age, and he connected that stiff matrix to the rise of cancer with aging. Source: The Cancer Matrix
He noted that before treatment became practically obligatory, some people lived into old age with clearly malignant tumors and died of something else. Source: Breast Cancer
What he suggested in practice
- This page describes his published views. It is not treatment advice. Cancer needs an oncologist.
- The factors he wrote about reducing: polyunsaturated fat, estrogen exposure, endotoxin, radiation.
- The factors he wrote about supporting: thyroid function, progesterone, carbon dioxide, sugar oxidation, aspirin, niacinamide.
Where he wrote about it
This topic comes up in 92 of the articles on his site. These are the most relevant ones:
- Estrogen, progesterone, and cancer: Conflicts of interest in regulation and product promotion · original on raypeat.com ↗
- Breast Cancer · original on raypeat.com ↗
- Cancer: Disorder and Energy · original on raypeat.com ↗
- Preventing and treating cancer with progesterone · original on raypeat.com ↗
- Prostate Cancer · original on raypeat.com ↗
- The Cancer Matrix · original on raypeat.com ↗
- RU486, Cancer, Estrogen, and Progesterone · original on raypeat.com ↗
- Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer · original on raypeat.com ↗
Quick answers
What did Ray Peat say about cancer?
That it is a systemic, metabolic disease built on a defect in cellular respiration, promoted by estrogen, lactic acid, polyunsaturated fats and radiation, and opposed by progesterone, thyroid, carbon dioxide and aspirin.
Did Ray Peat recommend aspirin for cancer?
He wrote that when people with cancer asked for his recommendations he told them to use aspirin, and he cited research on its anti-metastatic effects. That is his view, not medical advice.
367 studies Ray Peat cited on cancer
- Anti-neoplastic action of aspirin against a T-cell lymphoma involves an alteration in the tumour microenvironment and regulation of tumour cell survivalBiosci Rep · 2012 · PMID 21692746 · cited in Cancer: Disorder and Energy
- Subcutaneous, omentum and tumor fatty acid composition, and serum insulin status in patients with benign or cancerous ovarian or endometrial tumors. Do tumors preferentially utilize polyunsaturated fatty acids?Cancer Lett · 1997 · PMID 9022144 · cited in Vitamin E: Estrogen antagonist, energy promoter, and anti-inflammatory
- Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expressionCancer Res · 1993 · PMID 8385577 · cited in Altitude and Mortality
- A study of estrogen and progesterone cytosol receptor concentration in benign and malignant ovarian tumors and a review of malignant ovarian tumors treated with medroxy-progesterone acetateActa Obstet Gynecol Scand Suppl · 1981 · PMID 6946676 · cited in A Physiological Approach to Ovarian Cancer
- Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasisCancer Res · 2001 · PMID 11221857 · cited in Bleeding, clotting, cancer
- Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolacInt J Cancer · 2001 · PMID 11275997 · cited in Fats and degeneration
- Effects of fish oil and corn oil diets on prostaglandin-dependent and myelopoiesis-associated immune suppressor mechanisms of mice bearing metastatic Lewis lung carcinoma tumorsCancer Res · 1989 · PMID 2522813 · cited in The Great Fish Oil Experiment
- Hormonal pattern in prostatic cancer. I. Correlation with local extent of tumour, presence of metastases and grade of differentiationActa Endocrinol (Copenh) · 1981 · PMID 7304085 · cited in Prostate Cancer
- Prostaglandin in human breast cancer: Evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cellsJ Natl Cancer Inst · 1980 · PMID 6767871 · cited in Prostate Cancer
- Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogensCancer Res · 2013 · PMID 23539447 · cited in The Cancer Matrix
- Cholinesterase activities and biochemical determinations in patients with prostate cancer: influence of Gleason score, treatment and bone metastasisBiomed Pharmacother · 2012 · PMID 22560633 · cited in The dark side of stress (learned helplessness)
- Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapyNat Med · 2011 · PMID 21725296 · cited in Cancer: Disorder and Energy
- Extranuclear signaling by estrogen: role in breast cancer progression and metastasisMinerva Ginecol · 2010 · PMID 21079578 · cited in Cancer: Disorder and Energy
- Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patientsBiosens Bioelectron · 2010 · PMID 20719496 · cited in The Cancer Matrix
- Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cellsJ Biol Chem · 2008 · PMID 18541534 · cited in Cancer: Disorder and Energy, Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancerInt J Cancer · 2008 · PMID 18302154 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironmentCancer Res · 2007 · PMID 18089798 · cited in The Cancer Matrix
- Reprogramming metastatic tumour cells with embryonic microenvironmentsNat Rev Cancer · 2007 · PMID 17384580 · cited in Stem cells, cell culture, and culture: Issues in regeneration
- Influence of estradiol on mammary tumor collagen solubility in DMBA-induced rat mammary tumorsCell Biol Int · 2006 · PMID 16388971 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)J Natl Cancer Inst · 2005 · PMID 15900045 · cited in Estrogen, progesterone, and cancer: Conflicts of interest in regulation and product promotion
- Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosisCarcinogenesis · 2005 · PMID 16033770 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Gene regulation profile reveals consistent anticancer properties of progesterone in hormone-independent breast cancer cells transfected with progesterone receptorInt J Cancer · 2005 · PMID 15945099 · cited in Preventing and treating cancer with progesterone
- Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stressJ Clin Pathol · 2005 · PMID 16189147 · cited in Preventing and treating cancer with progesterone
- Platelet serotonin 5-HT2A receptor binding in patients with carcinoid tumorScand J Clin Lab Invest · 2004 · PMID 15025423 · cited in Serotonin: Effects in disease, aging and inflammation
- [Urine diacetylspermine as a novel tumor marker for pancreatobiliary carcinomas]Rinsho Byori · 2004 · PMID 15164602 · cited in Meat physiology, stress, and degenerative physiology
- Reduction of human metastatic breast cancer cell aggressiveness on introduction of either form a or B of the progesterone receptor and then treatment with progestinsCancer Res · 2004 · PMID 15520195 · cited in Estrogen, progesterone, and cancer: Conflicts of interest in regulation and product promotion, Preventing and treating cancer with progesterone
- The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical modelsCancer Res · 2003 · PMID 12873971 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Malignancy as a solid-phase coagulopathy: implications for the etiology, pathogenesis, and treatment of cancerSemin Thromb Hemost · 2003 · PMID 12888928 · cited in Bleeding, clotting, cancer
- Heparin treatment of malignancy: the case for clinical trials in colon cancerThromb Res · 2003 · PMID 14512084 · cited in Bleeding, clotting, cancer
- Anticoagulants in cancer treatment: malignancy as a solid phase coagulopathyCancer Lett · 2002 · PMID 12183069 · cited in Bleeding, clotting, cancer
- Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesisInt J Cancer · 2001 · PMID 11477553 · cited in Aspirin, brain and cancer
- Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomasCarcinogenesis · 2001 · PMID 11238189 · cited in Autonomic systems
- Nitric oxide synthase inhibition promotes carcinogen-induced preneoplastic changes in the colon of ratsNitric Oxide · 2000 · PMID 11139366 · cited in Meat physiology, stress, and degenerative physiology
- Promotion of colon cancer metastases in rat liver by fish oil diet is not due to reduced stroma formationClin Exp Metastasis · 2000 · PMID 11467768 · cited in The Great Fish Oil Experiment, Fats and degeneration
- Dietary glycine inhibits the growth of B16 melanoma tumors in miceCarcinogenesis · 1999 · PMID 10334195 · cited in Gelatin, stress, longevity
- The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black TeaProc Soc Exp Biol Med · 1999 · PMID 10202397 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
- Dietary lignin, and insoluble fiber, enhance uterine cancer but did not influence mammary cancer induced by N-methyl-N-nitrosourea in ratsNutr Cancer · 1998 · PMID 9682245 · cited in Natural Estrogens
- Diminution of the development of experimental metastases produced by murine metastatic lines in essential fatty acid-deficient host miceClin Exp Metastasis · 1998 · PMID 10091936 · cited in The Great Fish Oil Experiment, Fats and degeneration
- Mortality in beagles irradiated during prenatal and postnatal development. II. Contribution of benign and malignant neoplasiaRadiat Res · 1998 · PMID 9728662 · cited in Breast Cancer
- Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituentCancer Res · 1998 · PMID 9751618 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
Showing 40 of 367. Search all of them in the database →
Not affiliated with raypeat.com. This page describes Ray Peat's published articles in our own words and links to the originals. Educational content, not medical advice.