Ray Peat on Carbon Dioxide (CO2)
Short answer: Ray Peat treated carbon dioxide as a protective substance, not a waste gas. He wrote that it opposes lactic acid, relaxes blood vessels, keeps calcium in the bones, and explains why people and animals living with more of it tend to live longer.
What Ray Peat wrote about carbon dioxide
He set carbon dioxide against lactic acid. When energy fails, lactic acid rises as carbon dioxide falls, cells swell and take up water. Raising carbon dioxide reverses that. Source: The transparency of life: Cataracts as a model of age-related disease, Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer, Mitochondria and mortality
He used long-lived animals as evidence. Queen bees, naked mole rats and bats all live in air with more carbon dioxide and outlive similar animals by a wide margin. Source: Protective CO2 and aging
Altitude was his human example. At altitude the body holds more carbon dioxide and makes less lactic acid, and he connects that to lower rates of several diseases, including cataracts. Source: Altitude and Mortality, The transparency of life: Cataracts as a model of age-related disease, Fatigue, aging, and recuperation
Carbon dioxide regulates minerals. It increases the absorption and retention of calcium and the excretion of phosphate, and allows calcium to be laid down in bone. Source: Phosphate, activation, and aging
It relaxes blood vessels and bronchial muscle, and supports the delivery of oxygen. Hyperventilation, which blows it off, increases the leakiness of capillaries. Source: Phosphate, activation, and aging, Bleeding, clotting, cancer
Simply increasing carbon dioxide lowers lactic acid and ammonia and raises GABA, the calming transmitter. Source: Fatigue, aging, and recuperation
Thyroid hormone is the main source: it keeps oxidative metabolism running, and oxidizing sugar produces more carbon dioxide than oxidizing fat. Source: Water: swelling, tension, pain, fatigue, aging
What he suggested in practice
- Breathing into a paper bag for a minute or two at a time, which he suggests for lowering blood pressure and steadying heart rhythm.
- Enough calcium, and sometimes extra salt and baking soda, to raise the carbon dioxide held in the tissues.
- Vitamin B1 to increase carbon dioxide and reduce lactate.
- Sugar and thyroid function, which decide how much you produce.
Where he wrote about it
This topic comes up in 62 of the articles on his site. These are the most relevant ones:
- Altitude and Mortality · original on raypeat.com ↗
- Protective CO2 and aging · original on raypeat.com ↗
- Genes, Carbon Dioxide and Adaptation · original on raypeat.com ↗
- The transparency of life: Cataracts as a model of age-related disease · original on raypeat.com ↗
- Osteoporosis, harmful calcification, and nerve/muscle malfunctions · original on raypeat.com ↗
- Bone Density: First Do No Harm · original on raypeat.com ↗
- Phosphate, activation, and aging · original on raypeat.com ↗
- Water: swelling, tension, pain, fatigue, aging · original on raypeat.com ↗
My take
Carbon dioxide is the main vasodilator in the body and the gut's best friend. It lowers the pH of the colon, suppresses Gram-negative bacteria and stabilizes mast cells. More carbs burned well means more CO2.
Quick answers
What did Ray Peat say about carbon dioxide?
That it is a protective substance that opposes lactic acid, stabilizes cells, relaxes blood vessels and helps the body keep calcium in bone.
How did Ray Peat suggest increasing CO2?
By supporting thyroid function and sugar oxidation, getting enough calcium, sometimes using salt and baking soda, taking vitamin B1, and breathing into a paper bag for a minute or two.
What did Ray Peat say about bag breathing?
He describes breathing into a paper bag for a minute or two at a time as an easy way to raise the carbon dioxide in the blood, lower blood pressure and improve heart rhythm.
124 studies Ray Peat cited on carbon dioxide
- Lactate as a modulator of hypoxia-induced hyperventilationRespir Physiol Neurobiol · 2003 · PMID 14519376 · cited in Bleeding, clotting, cancer
- Effects of hypercapnia and hypocapnia on [Ca2+]i mobilization in human pulmonary artery endothelial cellsJ Appl Physiol (1985) · 2001 · PMID 11356771 · cited in Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy
- Type II Na-Pi cotransport is regulated transcriptionally by ambient bicarbonate/carbon dioxide tension in OK cellsAm J Physiol · 1999 · PMID 9887079 · cited in Phosphate, activation, and aging
- Effects of hyperventilation and hypocapnic/normocapnic hypoxemia on renal function and lithium clearance in humansAnesthesiology · 1998 · PMID 9856713 · cited in Bone Density: First Do No Harm
- [New evidence for the inhibitory action of CO2 on generation of superoxide anion radicals by phagocytes in various tissues. (Mechanism of bio- and eco-effects of CO2)]Dokl Akad Nauk · 1996 · PMID 8924865 · cited in Protective CO2 and aging
- Hyperlactatemia associated with hypocarbic hyperventilationActa Anaesthesiol Scand · 1996 · PMID 8904274 · cited in Altitude and Mortality
- Will a critical level of hyperventilation-induced hypocapnia always induce an absence seizure?Epilepsia · 1996 · PMID 8617175 · cited in Epilepsy and Progesterone
- The roles of bicarbonate and CO2 in transendothelial fluid movement and control of corneal thicknessInvest Ophthalmol Vis Sci · 1995 · PMID 7822137 · cited in The transparency of life: Cataracts as a model of age-related disease
- Effects of medium acidification by alteration of carbon dioxide or bicarbonate concentrations on the resorptive activity of rat osteoclastsJ Bone Miner Res · 1994 · PMID 8191931 · cited in Osteoporosis, harmful calcification, and nerve/muscle malfunctions
- Role of carbonic anhydrase in bone resorption: effect of acetazolamide on basal and parathyroid hormone-induced bone metabolismCalcif Tissue Int · 1987 · PMID 3034387 · cited in Osteoporosis, aging, tissue renewal, and product science
- Effects of chronic normobaric hypoxic and hypercapnic exposure in rats: prevention of experimental chronic mountain sickness by hypercapniaInt J Biometeorol · 1987 · PMID 3666983 · cited in Preventing and treating cancer with progesterone
- Acid-base balance and blood lactate and pyruvate levels in albino rats bred under normobaric hypoxia or normoxia, after muscular work in a hypoxic or hypoxic-hypercapnic environmentRev Pneumol Clin · 1986 · PMID 3809871 · cited in Mitochondria and mortality
- Antipsychotic and prophylactic effects of acetazolamide (Diamox) on atypical psychosisFolia Psychiatr Neurol Jpn · 1984 · PMID 6442984 · cited in Thyroid, insomnia, and the insanities: Commonalities in disease
- Phasic changes in bone CO2 fractions, calcium, and phosphorus during chronic hypercapniaJ Appl Physiol Respir Environ Exerc Physiol · 1980 · PMID 6778848 · cited in Osteoporosis, harmful calcification, and nerve/muscle malfunctions
- [CO2 storage in various organs during chronic experimental hypercapnia (author's transl)]Bull Eur Physiopathol Respir · 1976 · PMID 1016773 · cited in Osteoporosis, harmful calcification, and nerve/muscle malfunctions
- The phosphaturic effect of sodium bicarbonate and acetazolamide in dogsJ Clin Invest · 1968 · PMID 5645865 · cited in Phosphate, activation, and aging
- Lactate: a metabolic key player in cancerCancer Res · 2011 · PMID 22084445 · cited in Cancer: Disorder and Energy
- Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium levelsAllergy · 2011 · PMID 21284650 · cited in Cancer: Disorder and Energy
- Lysyl oxidase-like-1 enhances lung metastasis when lactate accumulation and monocarboxylate transporter expression are involvedOncol Lett · 2011 · PMID 22866136 · cited in The Cancer Matrix
- Chronic hypercapnia alters lung matrix composition in mouse pupsJ Appl Physiol (1985) · 2010 · PMID 20360436 · cited in The Cancer Matrix
- Effects of high-altitude hypoxia on the hormonal response to hypothalamic factorsAm J Physiol Regul Integr Comp Physiol · 2010 · PMID 20926759 · cited in Osteoporosis, aging, tissue renewal, and product science
- Hypercapnic acidosis in ventilator-induced lung injuryIntensive Care Med · 2010 · PMID 20213072 · cited in Regeneration and degeneration: Types of inflammation change with aging
- Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbitsIntensive Care Med · 2009 · PMID 18626629 · cited in Regeneration and degeneration: Types of inflammation change with aging
- Heated and humidified CO2 prevents hypothermia, peritoneal injury, and intra-abdominal adhesions during prolonged laparoscopic insufflationsJ Surg Res · 2009 · PMID 18639246 · cited in Regeneration and degeneration: Types of inflammation change with aging
- Intraoperative field flooding with warm humidified CO2 may help to prevent adhesion formation after open surgeryMed Hypotheses · 2009 · PMID 19589645 · cited in Regeneration and degeneration: Types of inflammation change with aging
- Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancerCancer Res · 2008 · PMID 18451179 · cited in Cancer: Disorder and Energy
- In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and IIBioorg Med Chem · 2008 · PMID 18819808 · cited in Cancer: Disorder and Energy
- Lactate production and neurotransmitters; evidence from microdialysis studiesPharmacol Biochem Behav · 2008 · PMID 18502489 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and aminesBioorg Med Chem Lett · 2007 · PMID 17540561 · cited in Cancer: Disorder and Energy
- Role of hypercapnia in brain oxygenation in sleep-disordered breathingActa Neurobiol Exp (Wars) · 2007 · PMID 17691228 · cited in Protective CO2 and aging
- Lactate treatment causes NF-kappaB activation and CD44 shedding in cultured trabecular meshwork cellsInvest Ophthalmol Vis Sci · 2007 · PMID 17389491 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Hypoxia and lactate production in trophoblast cellsPlacenta · 2007 · PMID 17275903 · cited in Salt, energy, metabolic rate, and longevity
- Embryonic exposure to o,p'-DDT causes eggshell thinning and altered shell gland carbonic anhydrase expression in the domestic henEnviron Toxicol Chem · 2006 · PMID 17022422 · cited in Osteoporosis, aging, tissue renewal, and product science
- Effect of CO2 on LPS-induced cytokine responses in rat alveolar macrophagesAm J Physiol Lung Cell Mol Physiol · 2005 · PMID 15778246 · cited in Regeneration and degeneration: Types of inflammation change with aging
- Sodium lactate increases LPS-stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappaB transcriptional activitiesAm J Physiol Endocrinol Metab · 2005 · PMID 15941782 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Enhancement of lactate metabolism in the basolateral amygdala by physical and psychological stress: role of benzodiazepine receptorsBrain Res · 2005 · PMID 16309628 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Lactate induced excitotoxicity in hippocampal slice culturesExp Neurol · 2004 · PMID 14980811 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Hypercapnic acidosis attenuates endotoxin-induced acute lung injuryAm J Respir Crit Care Med · 2004 · PMID 12958048 · cited in Preventing and treating cancer with progesterone
- Possible role of arachidonic acid in the regulation of lactate production in rat Sertoli cellsInt J Androl · 2003 · PMID 14511220 · cited in Cancer: Disorder and Energy
- Chronic acidosis-induced alteration in bone bicarbonate and phosphateAm J Physiol Renal Physiol · 2003 · PMID 12759230 · cited in Osteoporosis, aging, tissue renewal, and product science
Showing 40 of 124. Search all of them in the database →
Not affiliated with raypeat.com. This page describes Ray Peat's published articles in our own words and links to the originals. Educational content, not medical advice.