Ray Peat: Mitochondria and mortality

Lactate, glycolysis, and suppressed respiration

1. The effect of mitochondrial dysfunction on glucose metabolism during shockAdv Shock Res · 1978 · PMID 262075
2. Effect of sodium dichloroacetate on human pyruvate metabolismBrain Dev · 1989 · PMID 2751069
3. Effect of lactate and beta-hydroxybutyrate infusions on brain metabolism in the fetal sheepJ Dev Physiol · 1990 · PMID 2100739 · cited in Altitude and Mortality
4. Metabolic correlates of fatigue from different types of exercise in manAdv Exp Med Biol · 1995 · PMID 8585450

Carbon dioxide, hypoxia, and altitude adaptation

1. Post-hypercapnia recovery in the dog: arterial blood acid-base equilibrium and glycolysisRespir Physiol · 1977 · PMID 609852
2. Acid-base balance and blood lactate and pyruvate levels in albino rats bred under normobaric hypoxia or normoxia, after muscular work in a hypoxic or hypoxic-hypercapnic environmentRev Pneumol Clin · 1986 · PMID 3809871
3. Metabolic and work efficiencies during exercise in Andean nativesJ Appl Physiol (1985) · 1991 · PMID 2055851 · cited in Altitude and Mortality

Exercise, mtDNA, and respiratory repair

1. Exercise-induced alterations of hepatic mitochondrial functionBiochem J · 1982 · PMID 7165727
2. Acute exercise causes mitochondrial DNA deletion in rat skeletal muscleMuscle Nerve · 1999 · PMID 10024140
3. Gene shifting: a novel therapy for mitochondrial myopathyHum Mol Genet · 1999 · PMID 10332036

Shock, lactated Ringer's, resuscitation, and apoptosis

1. Small-volume resuscitation using hypertonic saline improves organ perfusion in burned ratsAnesth Analg · 1996 · PMID 8831321
2. The effects of diaspirin cross-linked hemoglobin on hemodynamics, metabolic acidosis, and survival in burned ratsJ Trauma · 1999 · PMID 10029035
3. Resuscitation with lactated Ringer's solution in rats with hemorrhagic shock induces immediate apoptosisJ Trauma · 1999 · PMID 10217219

Fatty acids, palmitate, cardiolipin, and the Randle cycle

1. Glycolysis inhibition by palmitate in renal cells cultured in a two-chamber systemAm J Physiol · 1997 · PMID 9374661
2. The role of glucose in the regulation of substrate interaction during exerciseCan J Appl Physiol · 1998 · PMID 9822792
3. Effect of lipid oxidation on glucose utilization in humansAm J Clin Nutr · 1998 · PMID 9497164
4. Structural details of an interaction between cardiolipin and an integral membrane proteinProc Natl Acad Sci U S A · 1999 · PMID 10611277

Hormones and neurosteroids

1. Neurosteroid inhibition of cell deathAm J Physiol · 1997 · PMID 9435674

Nitric oxide, calcium, and cell death

1. Cell calcium, cell injury and cell deathEnviron Health Perspect · 1984 · PMID 6437806
2. Protection against hypoxic injury in isolated-perfused rat heart by ruthenium redJ Pharmacol Exp Ther · 1990 · PMID 1692589
3. Nitric oxide activates the glucose-dependent mobilization of arachidonic acid in a macrophage-like cell line (RAW 264.7) that is largely mediated by calcium-independent phospholipase A2J Biol Chem · 1995 · PMID 7797462
4. Glucose and pyruvate regulate cytokine-induced nitric oxide production by cardiac myocytesAm J Physiol · 1996 · PMID 8897830
5. Neural injury, repair and adaptation in the GI tract. I. New insights into neuronal injury: a cautionary taleAm J Physiol · 1998 · PMID 9696720
6. Nitric oxide-induced damage to mtDNA and its subsequent repairNucleic Acids Res · 1999 · PMID 10536162

Aging, free radicals, and Alzheimer's

1. Lack of age-dependent changes in rat heart mitochondriaMech Ageing Dev · 1987 · PMID 3626646
2. Mitochondrial free radical production and aging in mammals and birdsAnn N Y Acad Sci · 1998 · PMID 9928433
3. Gene expression profile of aging and its retardation by caloric restrictionScience · 1999 · PMID 10464095
4. Mitochondrial involvement in Alzheimer's diseaseBiochim Biophys Acta · 1999 · PMID 10076025