Ray Peat on Estrogen
Short answer: Ray Peat described estrogen as a hormone of stress and aging, not of youth. He wrote that it rises with stress, low thyroid function and low protein intake, that polyunsaturated fats amplify it, and that progesterone, thyroid, vitamin E and aspirin oppose it.
What Ray Peat wrote about estrogen
He wrote that people under stress, with a thyroid deficiency, or who do not eat enough protein typically have elevated estrogen. Source: Natural Estrogens
The liver is the exit. A healthy liver inactivates practically all the estrogen that reaches it, and protein is needed for that work. When the liver is sluggish, estrogen stays in the body. Source: Tissue-bound estrogen in aging, Natural Estrogens, Multiple Sclerosis and other hormone related brain syndromes
Polyunsaturated fats stored in the tissues promote estrogen's action in several ways, and the effect builds up over the years. Source: Natural Estrogens
Estrogen is made in fat cells under the influence of cortisol. Progesterone and thyroid suppress that. Source: Breast Cancer
He rejected the idea of safe plant estrogens. He wrote that weak estrogens have the full range of harmful effects, and that soy products cause changes in women that appear to predispose to cancer. Source: Natural Estrogens
Estrogen lowers body temperature, depletes glycogen and, in his words, is the age stress hormone. Many toxic effects were already known by the middle of the 1900s. Source: Multiple sclerosis, protein, fats, and progesterone, Aging, estrogen, and progesterone, Estrogen — Age Stress Hormone
Opponents he names: progesterone, thyroid, vitamin E, which he calls an estrogen antagonist, and aspirin, which lowers estrogen production. Source: Aging, estrogen, and progesterone, Vitamin E: Estrogen antagonist, energy promoter, and anti-inflammatory, Aspirin, brain and cancer
He also noticed that antibiotics lowered estrogen and cortisol in women and animals, which he explained by less endotoxin reaching the liver. Source: Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
What he suggested in practice
- Enough protein, so the liver can eliminate estrogen.
- Correct low thyroid function.
- Remove polyunsaturated oils and soy.
- A daily raw carrot.
Where he wrote about it
This topic comes up in 84 of the articles on his site. These are the most relevant ones:
- Tissue-bound estrogen in aging · original on raypeat.com ↗
- Natural Estrogens · original on raypeat.com ↗
- Estrogen Receptors -- what do they explain? · original on raypeat.com ↗
- Estriol, DES, DDT, etc · original on raypeat.com ↗
- Preventing and treating cancer with progesterone · original on raypeat.com ↗
- Aging, estrogen, and progesterone · original on raypeat.com ↗
- Estrogen — Age Stress Hormone · original on raypeat.com ↗
- Progesterone, not estrogen, is the coronary protection factor of women · original on raypeat.com ↗
My take
Estrogen is sold as a youth hormone and acts like a stress signal. I keep it low with carrots and white button mushrooms, no seed oils, a healthy gut and vitamin E, which I think is the most useful estrogen antagonist you can buy.
E-Complete Oral Supplementskin.foodView productQuick answers
What did Ray Peat say about estrogen?
He called it a hormone of stress and aging that promotes inflammation, water retention and abnormal growth, and wrote that progesterone and thyroid protect against it.
How did Ray Peat suggest lowering estrogen?
By supporting the liver with enough protein, correcting thyroid function, avoiding polyunsaturated fats and soy, eating a daily raw carrot, and using opposing substances such as progesterone, vitamin E and aspirin.
What did Ray Peat say about soy?
He wrote that the estrogens in soy are not safe or balanced, and that soy products produce changes that seem to predispose to cancer.
286 studies Ray Peat cited on estrogen
- Aromatase overexpression and breast hyperplasia, an in vivo model--continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glandsEndocr Relat Cancer · 1999 · PMID 10731124 · cited in Tissue-bound estrogen in aging, Preventing and treating cancer with progesterone
- Effects of estrone, estradiol, and estriol on hormone-responsive human breast cancer in long-term tissue cultureCancer Res · 1977 · PMID 870192 · cited in Estriol, DES, DDT, etc
- Human placental 17 beta-estradiol dehydrogenase. IV. Differentiation of 17 beta-estradiol-activated transhydrogenase from the transhydrogenase function of 17 beta-estradiol dehydrogenaseJ Biol Chem · 1969 · PMID 4389994 · cited in Cancer: Disorder and Energy
- Xenoestrogens are potent activators of nongenomic estrogenic responsesSteroids · 2007 · PMID 17174995 · cited in Osteoporosis, aging, tissue renewal, and product science
- Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influxMol Immunol · 2007 · PMID 17084457 · cited in Milk in context: allergies, ecology, and some myths
- Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogenJ Bone Miner Res · 2006 · PMID 16869728 · cited in Hot flashes, energy, and aging
- Functional significance of the rapid regulation of brain estrogen action: where do the estrogens come from?Brain Res · 2006 · PMID 16978590 · cited in Preventing and treating cancer with progesterone
- Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapyMenopause · 2005 · PMID 15772569 · cited in Hot flashes, energy, and aging
- Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alphaChem Res Toxicol · 2002 · PMID 11952337 · cited in Hot flashes, energy, and aging
- The effect of estrogens and antiestrogens in a rat model for hot flushMaturitas · 1998 · PMID 9881331 · cited in Hot flashes, energy, and aging
- Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estroneJ Steroid Biochem Mol Biol · 1998 · PMID 9605416 · cited in Natural Estrogens
- Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research GroupJAMA · 1998 · PMID 9718051 · cited in Progesterone, not estrogen, is the coronary protection factor of women
- Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4Proc Assoc Am Physicians · 1996 · PMID 8705735 · cited in Bone Density: First Do No Harm, Estrogen and Osteoporosis
- The endogenous estrogen metabolite 2-methoxyestradiol induces apoptotic neuronal cell death in vitroLife Sci · 1996 · PMID 8622572 · cited in Estrogen — Age Stress Hormone
- The other estrogen receptor in the plasma membrane: implications for the actions of environmental estrogensEnviron Health Perspect · 1995 · PMID 8593873 · cited in Estrogen Receptors -- what do they explain?
- Estrogenic control of monoamine oxidase A activity in human neuroblastoma cells expressing physiological concentrations of estrogen receptorEur J Pharmacol · 1995 · PMID 8549621 · cited in Alzheimer's: The problem of Alzheimer's disease as a clue to immortality — part 2
- Effect of estrogen withdrawal on energy-rich phosphates and prediction of estrogen dependence monitored by in vivo 31P magnetic resonance spectroscopy of four human breast cancer xenograftsCancer Res · 1995 · PMID 7712472 · cited in Epilepsy and Progesterone
- Clinical changes in ovariectomized ewes exposed to phytoestrogens and 17 beta-estradiol implantsProc Soc Exp Biol Med · 1995 · PMID 7892303 · cited in Estriol, DES, DDT, etc
- Influence of phytoestrogen diets on estradiol action in the rat uterusSteroids · 1994 · PMID 7974529 · cited in Estriol, DES, DDT, etc
- Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasiaJ Clin Endocrinol Metab · 1993 · PMID 8345057 · cited in Estrogen — Age Stress Hormone
- Placental estrogen synthetase (aromatase): evidence for phosphatase-dependent inactivationBiochem Biophys Res Commun · 1989 · PMID 2546553 · cited in Phosphate, activation, and aging
- Effect of the anti-oestrogen tamoxifen on the development of renal cortical necrosis induced by oestrone + vasopressin administration in ratsBr J Exp Pathol · 1988 · PMID 3377960 · cited in Aging, estrogen, and progesterone
- The endogenous concentration of estradiol and estrone in normal human postmenopausal endometriumJ Steroid Biochem · 1984 · PMID 6513559 · cited in Tissue-bound estrogen in aging, Preventing and treating cancer with progesterone
- Correlation of anti-inflammatory activity with inhibition of prostaglandin synthesis activity of nonsteroidal anti-estrogens and estrogens (38532)Proc Soc Exp Biol Med · 1975 · PMID 1121479 · cited in Aspirin, brain and cancer
- Studies on estrogen-sensitive transhydrogenase: the effect of estradiol-17 beta on alpha-ketoglutarate production in noncancerous and cancerous human breast tissueCancer · 1959 · PMID 13618864 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
- Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protectiveHeart Rhythm · 2012 · PMID 22245795 · cited in Heart and hormones
- Aromatase deficiency confers paradoxical postischemic cardioprotectionEndocrinology · 2011 · PMID 22028441 · cited in Heart and hormones
- The infusion of glucose in ewes during the luteal phase increases the number of follicles but reduces oestradiol production and some correlates of metabolic function in the large folliclesAnim Reprod Sci · 2011 · PMID 21943503 · cited in Hot flashes, energy, and aging
- Extranuclear signaling by estrogen: role in breast cancer progression and metastasisMinerva Ginecol · 2010 · PMID 21079578 · cited in Cancer: Disorder and Energy
- Oestradiol levels in varicose vein blood of patients with and without pelvic vein incompetence (PVI): diagnostic implicationsEur J Vasc Endovasc Surg · 2010 · PMID 20202867 · cited in Heart and hormones
- Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veinsJ Vasc Surg · 2010 · PMID 20347696 · cited in Heart and hormones
- Estrogen promotes stress sensitivity in a prefrontal cortex-amygdala pathwayCereb Cortex · 2010 · PMID 20139149 · cited in Serotonin: Effects in disease, aging and inflammation
- Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal womenMenopause · 2010 · PMID 20616673 · cited in Hot flashes, energy, and aging
- Elevated serum estradiol/testosterone ratio in men with primary varicose veins compared with a healthy control groupAngiology · 2009 · PMID 18854341 · cited in Heart and hormones
- Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effectsJ Psychiatr Res · 2009 · PMID 18986658 · cited in Serotonin: Effects in disease, aging and inflammation
- Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nucleiNeuroscience · 2009 · PMID 19559077 · cited in Serotonin: Effects in disease, aging and inflammation
- Estradiol impairs hypothalamic molecular responses to hypoglycemiaBrain Res · 2009 · PMID 19445909 · cited in Hot flashes, energy, and aging
- Hypothalamic neuronal histamine signaling in the estrogen deficiency-induced obesityJ Neurochem · 2009 · PMID 19619143 · cited in Hot flashes, energy, and aging
- Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancerCancer Res · 2008 · PMID 18451179 · cited in Cancer: Disorder and Energy
- Nonsteroidal anti-inflammatory drug use and serum total estradiol in postmenopausal womenCancer Epidemiol Biomarkers Prev · 2008 · PMID 18349287 · cited in Hot flashes, energy, and aging
Showing 40 of 286. Search all of them in the database →
Not affiliated with raypeat.com. This page describes Ray Peat's published articles in our own words and links to the originals. Educational content, not medical advice.