Ray Peat: Hot flashes, energy, and aging

Not estrogen deficiency; progesterone and glucose

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2. Progesterone for hot flush and night sweat treatment--effectiveness for severe vasomotor symptoms and lack of withdrawal reboundGynecol Endocrinol · 2012 · PMID 22849758
3. The endocrinology of perimenopause: need for a paradigm shiftFront Biosci (Schol Ed) · 2011 · PMID 21196391
4. Menopausal hot flash frequency changes in response to experimental manipulation of blood glucoseNurs Res · 2003 · PMID 14501548
5. Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone lossObstet Gynecol · 1999 · PMID 10432132
6. Androgens and estrogens in relation to hot flushes during the menopausal transitionMaturitas · 2002 · PMID 11809345
7. Neuroendocrine modulation of the "menopause": insights into the aging brainAm J Physiol · 1999 · PMID 10600782
8. Aging of the female reproductive system: a window into brain agingRecent Prog Horm Res · 1997 · PMID 9238857 · cited in Estrogen — Age Stress Hormone

Ovary vs brain, imprinting, estrogen toxicity

1. Contribution of the ovary versus hypothalamus-pituitary to termination of estrous cycles in aging rats using ovarian transplantsBiol Reprod · 1982 · PMID 6810966
2. The increase of anterior pituitary dopamine in aging C57BL/6J female mice is caused by ovarian steroids, not intrinsic pituitary agingNeuroendocrinology · 1986 · PMID 3724983
3. Vitamin E protects hypothalamic beta-endorphin neurons from estradiol neurotoxicityEndocrinology · 1992 · PMID 1425446 · cited in Tissue-bound estrogen in aging, Estrogen — Age Stress Hormone
4. Similarities between morphine withdrawal in the rat and the menopausal hot flushLife Sci · 1983 · PMID 6835016

Heat loss, NO, serotonin, CRH, caffeine

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2. Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reactionJ Clin Invest · 1993 · PMID 8408641
3. Caffeine decreases exhaled nitric oxideThorax · 2002 · PMID 11923558
4. Caffeine-induced increases in the brain and plasma concentrations of neuroactive steroids in the ratPharmacol Biochem Behav · 2000 · PMID 10837842 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
5. Increases in plasma concentrations of steroids in the rat after the administration of caffeine: comparison with plasma disposition of caffeineJ Endocrinol · 1988 · PMID 3199059
6. Effects of adrenocortical and gonadal steroids on the secretion in vitro of corticotrophin and its hypothalamic releasing factorJ Endocrinol · 1982 · PMID 6279755
7. Regulation of corticotropin-releasing factor secretion in vitro by glucoseAm J Physiol · 1988 · PMID 2901813
8. Effects of hypoglycaemia on neurotransmitter and hormone receptor gene expression in laser-dissected arcuate neuropeptide Y/agouti-related peptide neuronesJ Neuroendocrinol · 2010 · PMID 20298458
9. Estradiol impairs hypothalamic molecular responses to hypoglycemiaBrain Res · 2009 · PMID 19445909
10. Microvascular effects of corticotropin-releasing hormone in human skin vary in relation to estrogen concentration during the menstrual cycleJ Endocrinol · 2005 · PMID 16002537

Aromatase, PUFA, NSAID, lifespan

1. Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapyMenopause · 2005 · PMID 15772569
2. Unsaturated fatty acids stimulate LH secretion via novel PKCepsilon and -theta in gonadotrope cells and inhibit GnRH-induced LH releaseEndocrinology · 2011 · PMID 21862612
3. Nonsteroidal anti-inflammatory drug use and serum total estradiol in postmenopausal womenCancer Epidemiol Biomarkers Prev · 2008 · PMID 18349287
4. Pituitary removal in adult mice increases life spanMech Ageing Dev · 2006 · PMID 16643985
5. Sex steroids in reproductive tract tissues: regulation of estradiol concentrations by progesteroneBiol Reprod · 1976 · PMID 822889 · cited in Preventing and treating cancer with progesterone

More references from this article

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