Ray Peat: Tissue-bound estrogen in aging

Tissue vs plasma concentrations

1. Comparison of plasma and myometrial tissue concentrations of estradiol-17 beta and progesterone in nonpregnant womenContraception · 1981 · PMID 7273763 · cited in Preventing and treating cancer with progesterone
2. Interrelations between plasma and tissue concentrations of 17 beta-oestradiol and progesterone during human pregnancyClin Endocrinol (Oxf) · 1979 · PMID 535167 · cited in Preventing and treating cancer with progesterone
3. Unconjugated estradiol in the myometrium of pregnancyEndocrinology · 1976 · PMID 991813 · cited in Preventing and treating cancer with progesterone
4. The endogenous concentration of estradiol and estrone in normal human postmenopausal endometriumJ Steroid Biochem · 1984 · PMID 6513559 · cited in Preventing and treating cancer with progesterone
5. Age-related changes in the female hormonal environment during reproductive lifeAm J Obstet Gynecol · 1987 · PMID 3618679 · cited in Rosacea, inflammation, and aging: The inefficiency of stress, Natural Estrogens
6. Characterization of reproductive hormonal dynamics in the perimenopauseJ Clin Endocrinol Metab · 1996 · PMID 8636357 · cited in Rosacea, inflammation, and aging: The inefficiency of stress, Preventing and treating cancer with progesterone

Progesterone inactivation, aromatase, sulfatase

1. Progesterone-induced inactivation of nuclear estrogen receptor in the hamster uterus is mediated by acid phosphataseBiochem Biophys Res Commun · 1982 · PMID 6918219 · cited in Preventing and treating cancer with progesterone
2. Progesterone-induced estrogen receptor-regulatory factor in hamster uterine nuclei: preliminary characterization in a cell-free systemEndocrinology · 1981 · PMID 7198029 · cited in Preventing and treating cancer with progesterone
3. Aromatase overexpression and breast hyperplasia, an in vivo model--continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glandsEndocr Relat Cancer · 1999 · PMID 10731124 · cited in Preventing and treating cancer with progesterone
4. Elevated steroid sulfatase expression in breast cancersJ Steroid Biochem Mol Biol · 2000 · PMID 10925213 · cited in Preventing and treating cancer with progesterone

Hypothalamic aging, mitochondria

1. Vitamin E protects hypothalamic beta-endorphin neurons from estradiol neurotoxicityEndocrinology · 1992 · PMID 1425446 · cited in Hot flashes, energy, and aging, Estrogen — Age Stress Hormone
2. Estrogen-induced hypothalamic beta-endorphin neuron loss: a possible model of hypothalamic agingExp Gerontol · 1995 · PMID 7556506 · cited in Alzheimer's: The problem of Alzheimer's disease as a clue to immortality — part 2, Epilepsy and Progesterone
3. Rapid inhibition of rat brain mitochondrial proton F0F1-ATPase activity by estrogens: comparison with Na+, K+ -ATPase of porcine cortexEur J Pharmacol · 1999 · PMID 10096774
4. Purification and identification of an estrogen binding protein from rat brain: oligomycin sensitivity-conferring protein (OSCP), a subunit of mitochondrial F0F1-ATP synthase/ATPaseJ Steroid Biochem Mol Biol · 1999 · PMID 10215039

More references from this article

1. [The nature of thyroid hormone receptors. Intracellular functions of thyroxine-binding prealbumin]Biokhimiia · 1985 · PMID 2415173 · cited in Thyroid: Therapies, Confusion, and Fraud
2. Tissue specific effects of progesterone on progesterone and estrogen receptors in the female urogenital tractJ Steroid Biochem · 1989 · PMID 2913398 · cited in Preventing and treating cancer with progesterone
3. Female sex steroid concentrations in the ampullary and isthmic regions of the human fallopian tube and their relationship to plasma concentrations during the menstrual cycleAm J Obstet Gynecol · 1980 · PMID 7369272
4. Sex steroids in plasma and reproductive tissues of the female guinea pigBiol Reprod · 1980 · PMID 7388097
5. Steroid control and sexual differentiation of brain aromataseJ Steroid Biochem Mol Biol · 1997 · PMID 9365208
6. [Hormone profile of elderly women and potential modifiers]Geburtshilfe Frauenheilkd · 1994 · PMID 8088487
7. Peripheral blood concentrations of progesterone and oestradiol during human pregnancy and deliveryActa Physiol Hung · 1985 · PMID 4013779
8. Estrogen and progesterone receptor and hormone levels in human myometrium and placenta in term pregnancyAm J Obstet Gynecol · 1984 · PMID 6496580
9. Hormonal reproductive status of women at menopausal transition compared to that observed in a group of midreproductive-aged womenClin Exp Obstet Gynecol · 2000 · PMID 10758802 · cited in Preventing and treating cancer with progesterone
10. Uptake and concentration of steroid hormones in mammary tissuesAnn N Y Acad Sci · 1986 · PMID 2942072 · cited in Preventing and treating cancer with progesterone
11. Sex hormone concentrations in post-menopausal womenClin Endocrinol (Oxf) · 1978 · PMID 679502 · cited in Preventing and treating cancer with progesterone
12. Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiolJ Clin Endocrinol Metab · 1998 · PMID 9851796
13. Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complexBiochem Biophys Res Commun · 1999 · PMID 10425214