Ray Peat: Suitable Fats, Unsuitable Fats: Issues in Nutrition

PUFA mitochondria, ROS, aging membranes

1. Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species generationFree Radic Biol Med · 1999 · PMID 10443919 · cited in Fats and degeneration
2. Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damageMech Ageing Dev · 2001 · PMID 11240164 · cited in Fats and degeneration
3. On the importance of fatty acid composition of membranes for agingJ Theor Biol · 2005 · PMID 15757684 · cited in Unsaturated fatty acids: Nutritionally essential, or toxic?
4. Extended longevity of wild-derived mice is associated with peroxidation-resistant membranesMech Ageing Dev · 2006 · PMID 16620917
5. Modulation of cardiac mitochondrial membrane fluidity by age and calorie intakeFree Radic Biol Med · 1999 · PMID 9895215 · cited in Fats, functions & malfunctions, Unsaturated fatty acids: Nutritionally essential, or toxic?

PUFA toxicity, Israeli paradox, diabetes

1. Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicalsBiochem Pharmacol · 1990 · PMID 1690007 · cited in Fats and degeneration
2. Diet and disease--the Israeli paradox: possible dangers of a high omega-6 polyunsaturated fatty acid dietIsr J Med Sci · 1996 · PMID 8960090
3. Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intakeDiabetes · 2005 · PMID 16046296
4. Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1J Biol Chem · 2002 · PMID 11741998
5. Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oilsJ Nutr · 2000 · PMID 11110863 · cited in The Great Fish Oil Experiment, Aging Eyes, Infant Eyes, and Excitable Tissues

More references from this article

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16. Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs alpha 1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytesNaunyn Schmiedebergs Arch Pharmacol · 1996 · PMID 8857587
17. Effects of dietary n-3-to-n-6 polyunsaturated fatty acid ratio on mammary carcinogenesis in ratsNutr Cancer · 1998 · PMID 9589432 · cited in Fats and degeneration
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