Ray Peat: Fats, functions & malfunctions

Longevity, unsaturation, naked mole-rat

1. Disparate patterns of age-related changes in lipid peroxidation in long-lived naked mole-rats and shorter-lived miceAging Cell · 2006 · PMID 17129214
2. Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomicsExp Gerontol · 2007 · PMID 18029129
3. Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammalsMech Ageing Dev · 2000 · PMID 10687923 · cited in Aging Eyes, Infant Eyes, and Excitable Tissues
4. Free radicals and agingTrends Neurosci · 2004 · PMID 15374670

Saturated fat protection vs PUFA shock and fibrosis

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2. Resistance of essential fatty acid-deficient rats to endotoxin-induced increases in vascular permeabilityCirc Shock · 1990 · PMID 2188748 · cited in Glucose and sucrose for diabetes, Multiple sclerosis, protein, fats, and progesterone
3. Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administrationJ Pharmacol Exp Ther · 2001 · PMID 11602676 · cited in Fats and degeneration
4. Effect of dietary stearic acid on the genesis of spontaneous mammary adenocarcinomas in strain A/ST miceInt J Cancer · 1984 · PMID 6490204 · cited in Cancer: Disorder and Energy
5. Prognostic significance of tumor phosphatidylcholine stearic acid level in breast carcinomaBreast Cancer Res Treat · 1992 · PMID 1571571
6. Dietary supplementation of old rats with hydrogenated peanut oil restores activities of mitochondrial respiratory complexes in skeletal musclesBiochemistry (Mosc) · 2010 · PMID 21314620

PUFA leak, arrhythmia, estrogen, brain

1. Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by antioxidantsEur J Pharmacol · 2003 · PMID 12679157
2. Arachidonic acid increases cerebral microvascular permeability by free radicals in single pial microvessels of the anaesthetized ratJ Physiol · 1998 · PMID 9518711 · cited in Fats and degeneration
3. Ingestion of (n-3) fatty acids augments basal and platelet activating factor-induced permeability to dextran in the rat mesenteric vascular bedJ Nutr · 2011 · PMID 21775525
4. Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig heartsCardiovasc Res · 2007 · PMID 17116294
5. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effectsAm J Clin Nutr · 2004 · PMID 15531662 · cited in Unsaturated fatty acids: Nutritionally essential, or toxic?
6. Gender differences in the n-3 fatty acid content of tissuesProc Nutr Soc · 2008 · PMID 18234128
7. Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayersAm J Clin Nutr · 1989 · PMID 2563626

Nuclear lipids, cardiolipin, cytoskeleton, synuclein

1. Modification of the Ehrlich ascites tumor cell nuclear lipidsBiochim Biophys Acta · 1976 · PMID 990304
2. Cardiolipins and biomembrane functionBiochim Biophys Acta · 1992 · PMID 1550861
3. Age-dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipinFEBS Lett · 1997 · PMID 9109403
4. Effects of free fatty acids on the organization of cytoskeletal elements in lymphocytesMol Cell Biol · 1981 · PMID 7202114
5. Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicityJ Neurosci · 2006 · PMID 16837598

More references from this article

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