Ray Peat: Rosacea, inflammation, and aging: The inefficiency of stress

Riboflavin, eye, skin, and photodamage

1. Analysis of flavins in ocular tissues of the rabbitInvest Ophthalmol Vis Sci · 1991 · PMID 2055692
2. Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental modelsEur J Pharmacol · 2006 · PMID 16962092
3. Nicotinic acid/niacinamide and the skinJ Cosmet Dermatol · 2004 · PMID 17147561
4. Health effects of sunlight exposure in the United States. Results from the first National Health and Nutrition Examination Survey, 1971-1974Arch Dermatol · 1988 · PMID 3257372
5. Remission of rosacea induced by reduction of gut transit timeClin Exp Dermatol · 2004 · PMID 15115515
6. Protection from photodamage by topical application of caffeine after ultraviolet irradiationBr J Dermatol · 2007 · PMID 17388926

Estrogen, fibrosis, and age

1. Age-related changes in the female hormonal environment during reproductive lifeAm J Obstet Gynecol · 1987 · PMID 3618679 · cited in Natural Estrogens, Tissue-bound estrogen in aging
2. New roles for estrogens in rheumatoid arthritisClin Exp Rheumatol · 2003 · PMID 14740444
3. Tissue-specific synthesis and oxidative metabolism of estrogensJ Natl Cancer Inst Monogr · 2000 · PMID 10963622
4. Effects of estradiol-17beta on expression of mRNA for seven angiogenic factors and their receptors in the endometrium of ovariectomized (OVX) ewesEndocrine · 2006 · PMID 17526946

Respiration, HNE, glutamate, NO, adenosine, caffeine

1. Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cellsCirc Res · 1992 · PMID 1394884
2. Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenalBiochemistry · 1998 · PMID 9843389
3. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenalBiochemistry · 1998 · PMID 9425076
4. 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sitesJ Neurochem · 1999 · PMID 10098869
5. Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal culturesFree Radic Biol Med · 2000 · PMID 11053772 · cited in The Great Fish Oil Experiment
6. Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slicesJ Neurochem · 2000 · PMID 10800947
7. Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slicesNeuropharmacology · 2000 · PMID 10760373 · cited in Aspirin, brain and cancer
8. Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosisBr J Pharmacol · 2006 · PMID 16783407
9. Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cellsMol Pharmacol · 2007 · PMID 17488804
10. Effect of caffeine on cerebral blood flow response to somatosensory stimulationJ Cereb Blood Flow Metab · 2005 · PMID 15703695
11. Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the ratHepatology · 1997 · PMID 9397995 · cited in Estrogen and Osteoporosis, Fats and degeneration
12. Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortexJ Physiol · 1994 · PMID 7514666 · cited in The Great Fish Oil Experiment
13. Effects of arachidonic acid on glutamate and gamma-aminobutyric acid uptake in primary cultures of rat cerebral cortical astrocytes and neuronsJ Neurochem · 1986 · PMID 2875129 · cited in The Great Fish Oil Experiment, Aging Eyes, Infant Eyes, and Excitable Tissues

More references from this article

1. [Clinical contribution on riboflavin deficiency of the eye]Boll Ocul · 1955 · PMID 14389481
2. [Receptor mediated effects of adenosine and caffeine]Tidsskr Nor Laegeforen · 1998 · PMID 9599504
3. [The effects of vitamin B2 group on the corneal metabolism. I]Nippon Ganka Gakkai Zasshi · 1961 · PMID 13895903
4. Riboflavin and the corneaQ Bull Northwest Univ Med Sch · 1952 · PMID 14930207
5. Comorbidity of rosacea and depression: an analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Care Survey--Outpatient Department data collected by the U.S. National Center for Health Statistics from 1995 to 2002Br J Dermatol · 2005 · PMID 16307654
6. Contribution to the ocular manifestation of riboflavin deficiencyTohoku J Exp Med · 1954 · PMID 14359322
7. Changes of body temperature and thermoregulatory responses of freely moving rats during GABAergic pharmacological stimulation to the preoptic area and anterior hypothalamus in several ambient temperaturesBrain Res · 2005 · PMID 15913569
8. Migraine and recurrent epistaxis in childrenPediatr Neurol · 2005 · PMID 16087052
9. [Fibrosis and cirrhosis in the rabbit induced by diethylstilbestrol and its inhibition with progesterone]Medicina (B Aires) · 1985 · PMID 3841921
10. 4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implicationsAntioxid Redox Signal · 1999 · PMID 11229439 · cited in The Great Fish Oil Experiment
11. Further evidence for the role of fibrosis in the pathobiology of rhinophymaAnn Plast Surg · 2002 · PMID 12055435
12. Down-regulating causes of fibrosis with tamoxifen: a possible cellular/molecular approach to treat rhinophymaAnn Plast Surg · 2006 · PMID 16508362
13. Release of arachidonic acid by NMDA-receptor activation in the rat hippocampusNeurochem Res · 1991 · PMID 1686068 · cited in The Great Fish Oil Experiment
14. Acrolein inhibits respiration in isolated brain mitochondriaBiochim Biophys Acta · 2001 · PMID 11342003 · cited in The Great Fish Oil Experiment
15. Overexpression of transforming growth factor beta-2 and its receptor in rhinophyma: an alternative mechanism of pathobiologyAnn Plast Surg · 2000 · PMID 11092361
16. Diminished responsiveness to thyroid hormone in riboflavin-deficient ratsNature · 1969 · PMID 5796956
17. Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxiaJ Pharmacol Exp Ther · 2007 · PMID 17132813
18. Characterization of reproductive hormonal dynamics in the perimenopauseJ Clin Endocrinol Metab · 1996 · PMID 8636357 · cited in Tissue-bound estrogen in aging, Preventing and treating cancer with progesterone
19. Rosacea: a study of clinical patterns, blood flow, and the role of Demodex folliculorumJ Am Acad Dermatol · 1992 · PMID 1534568
20. [Effect of vitamin B1 and B2 on diseases of the cornea]Cesk Oftalmol · 1951 · PMID 14822039
21. Glucocorticoids decrease cytochrome c oxidase activity of isolated rat kidney mitochondriaFEBS Lett · 1998 · PMID 9755852 · cited in Salt, energy, metabolic rate, and longevity
22. The ocular manifestations of riboflavin deficiencyAm J Ophthalmol · 1950 · PMID 15425611
23. Conditioned corneal vascularity in riboflavin deficiency; report of a caseArch Ophthal · 1949 · PMID 15396860
24. [Variations of total vitamin B2 content in the cornea, iris and ciliary body and the blood of rabbits in stress. (A preliminary report)]Nihon Ganka Kiyo · 1962 · PMID 13984683
25. The effect of the lipid peroxidation product 4-hydroxynonenal and of its metabolite 4-hydroxynonenoic acid on respiration of rat kidney cortex mitochondriaFree Radic Res · 1996 · PMID 8804985
26. The bacterial endotoxin lipopolysaccharide causes rapid inappropriate excitation in rat cortexJ Neurochem · 1999 · PMID 9930737
27. [Corneal changes in riboflavin-deficient rats]Ophthalmologica · 1955 · PMID 14394645
28. [On the phlogogenic properties of lactic acid in animal experiments]Arzneimittelforschung · 1968 · PMID 5756245
29. Flushing reactions: consequences and mechanismsAnn Intern Med · 1981 · PMID 6169300
30. Diminished function of the somatotropic axis in older reproductive-aged womenJ Clin Endocrinol Metab · 1995 · PMID 7852528
31. [Skin changes from taking hormonal contraceptives]Med Monatsschr Pharm · 1981 · PMID 7242455