Ray Peat

Ray Peat on Coffee and Caffeine

By OxidativeState · · 23 articles · 55 studies

Short answer: Ray Peat called caffeine a vitamin-like nutrient. He wrote that coffee acts in parallel with thyroid and progesterone, protects the liver, supplies magnesium and B vitamins, and that its bad reputation comes from experiments with huge doses on an empty stomach.

What Ray Peat wrote about coffee

He compared caffeine to thyroid and progesterone. It raises the metabolic rate, and it increases progesterone in the blood and the brain. He saw women's premenstrual coffee craving as a sensible form of self-medication. Source: Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones

He treated coffee as food. It provides significant magnesium, plus niacin and vitamin B1. Source: Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones, Rosacea, inflammation, and aging: The inefficiency of stress, Phosphate, activation, and aging

He cites studies linking coffee to healthier liver enzymes and protection against alcoholic cirrhosis, and says coffee, tea and caffeine are protective against breast cancer. Source: Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones

He explained the scare stories. Bad effects usually come from large doses given quickly. The effect on blood pressure is slight and may not happen with normal use. Source: Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones

He stressed the sugar connection. Caffeine speeds up the burning of glucose, so coffee on an empty stomach mostly shows the effect of falling blood sugar and rising adrenaline. In animals, the harm from large amounts of caffeine in pregnancy was prevented by adding sugar to the diet. Source: Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones, Fatigue, aging, and recuperation

He wrote that caffeine protects cells in ways similar to niacinamide, and restrains an enzyme that produces free radicals under stress. Source: Rosacea, inflammation, and aging: The inefficiency of stress, Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones

Coffee with a meal strongly blocks iron absorption. He says he always tries to drink coffee with meat for that reason. Source: Iron's Dangers

What he suggested in practice

  • Drink it with food, not on an empty stomach.
  • Have it with sugar, since caffeine raises the use of glucose.
  • Coffee with meat, to block the absorption of iron.

Where he wrote about it

This topic comes up in 23 of the articles on his site. These are the most relevant ones:

My take

Coffee raises the metabolic rate and glucose oxidation, especially with sugar, calcium, gelatin and salt. That is how I drink it.

Quick answers

Did Ray Peat drink coffee?

Yes. In his article on iron he writes that he always tries to drink coffee with meat, because coffee taken with food blocks iron absorption.

What did Ray Peat say about caffeine?

He called it a vitamin-like nutrient with effects parallel to thyroid and progesterone, and wrote that it protects the liver and supplies magnesium, niacin and vitamin B1.

Should coffee be taken with sugar, according to Ray Peat?

He wrote that caffeine increases the oxidation of sugar, and that studies of coffee on an empty stomach are really measuring low blood sugar and adrenaline.

55 studies Ray Peat cited on coffee

  1. Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of teaCancer Res · 1997 · PMID 9205068 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  2. Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B lightNutr Cancer · 1999 · PMID 10368809 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  3. Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese womenNutr Cancer · 1998 · PMID 9507508 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  4. Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cellsMol Pharmacol · 2007 · PMID 17488804 · cited in Rosacea, inflammation, and aging: The inefficiency of stress
  5. Coffee consumption and human health--beneficial or detrimental?--Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitusMol Nutr Food Res · 2005 · PMID 15704241 · cited in Cholesterol, longevity, intelligence, and health
  6. Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicityBr J Pharmacol · 2003 · PMID 12711619 · cited in BSE ("mad cow"), scrapie, etc.: Stimulated amyloid degeneration and the toxic fats
  7. Association of coffee and caffeine intake with the risk of Parkinson diseaseJAMA · 2000 · PMID 10819950 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  8. [Receptor mediated effects of adenosine and caffeine]Tidsskr Nor Laegeforen · 1998 · PMID 9599504 · cited in Rosacea, inflammation, and aging: The inefficiency of stress
  9. Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituentCancer Res · 1998 · PMID 9751618 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  10. [Effect of tea extracts, catechin and caffeine against type-I allergic reaction]Yakugaku Zasshi · 1997 · PMID 9261215 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  11. Caffeine, theophylline, theobromine, and developmental growth of the mouse mammary glandJ Environ Pathol Toxicol Oncol · 1992 · PMID 1625188 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  12. Increases in plasma concentrations of steroids in the rat after the administration of caffeine: comparison with plasma disposition of caffeineJ Endocrinol · 1988 · PMID 3199059 · cited in Hot flashes, energy, and aging
  13. Protection from photodamage by topical application of caffeine after ultraviolet irradiationBr J Dermatol · 2007 · PMID 17388926 · cited in Rosacea, inflammation, and aging: The inefficiency of stress
  14. Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxiaJ Pharmacol Exp Ther · 2007 · PMID 17132813 · cited in Rosacea, inflammation, and aging: The inefficiency of stress
  15. Long-term consumption of caffeine improves glucose homeostasis by enhancing insulinotropic action through islet insulin/insulin-like growth factor 1 signaling in diabetic ratsMetabolism · 2007 · PMID 17445533 · cited in Glucose and sucrose for diabetes
  16. Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosisBr J Pharmacol · 2006 · PMID 16783407 · cited in Rosacea, inflammation, and aging: The inefficiency of stress
  17. Effect of caffeine on cerebral blood flow response to somatosensory stimulationJ Cereb Blood Flow Metab · 2005 · PMID 15703695 · cited in Rosacea, inflammation, and aging: The inefficiency of stress
  18. Effect of caffeine on metabolism of L-arginine in the brainMol Cell Biochem · 2003 · PMID 12701820 · cited in Hot flashes, energy, and aging
  19. Caffeine decreases exhaled nitric oxideThorax · 2002 · PMID 11923558 · cited in Hot flashes, energy, and aging
  20. Caffeine-induced increases in the brain and plasma concentrations of neuroactive steroids in the ratPharmacol Biochem Behav · 2000 · PMID 10837842 · cited in Hot flashes, energy, and aging, Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  21. Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E(2) synthesis in rat microglial cellsNeuropharmacology · 2000 · PMID 10963764 · cited in Hot flashes, energy, and aging
  22. Effects of coffee consumption against the development of liver dysfunction: a 4-year follow-up study of middle-aged Japanese male office workersInd Health · 2000 · PMID 10680318 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  23. The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black TeaProc Soc Exp Biol Med · 1999 · PMID 10202397 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  24. Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese malesBr J Nutr · 1999 · PMID 10743484 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  25. Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estroneJ Steroid Biochem Mol Biol · 1998 · PMID 9605416 · cited in Natural Estrogens
  26. Development of porous defects in plasma membranes of adenosine triphosphate-depleted Madin-Darby canine kidney cells and its inhibition by glycineLab Invest · 1998 · PMID 9645756 · cited in Bleeding, clotting, cancer
  27. Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkersInt J Epidemiol · 1998 · PMID 9698132 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  28. Serotonin inhibition of 1-methylxanthine metabolism parallels its vasoconstrictor activity and inhibition of oxygen uptake in perfused rat hindlimbActa Physiol Scand · 1997 · PMID 9366958 · cited in Osteoporosis, aging, tissue renewal, and product science
  29. Dietary caffeine intake and bone status of postmenopausal womenAm J Clin Nutr · 1997 · PMID 9174479 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  30. Suppression by coffee cherry of the growth of spontaneous mammary tumours in SHN miceAnticancer Res · 1996 · PMID 8615601 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  31. Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweolCarcinogenesis · 1996 · PMID 8968051 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  32. Anti-hyperglycemic effect of black tea (Camellia sinensis) in ratJ Ethnopharmacol · 1995 · PMID 7623488 · cited in Glycemia, starch, and sugar in context, Diabetes, scleroderma, oils and hormones
  33. Adenosine modulates N-methyl-D-aspartate-stimulated hippocampal nitric oxide production in vivoStroke · 1995 · PMID 7544925 · cited in Altitude and Mortality
  34. Adenosines scavenged hydroxyl radicals and prevented posttraumatic epilepsyFree Radic Biol Med · 1995 · PMID 7590396 · cited in Alzheimer's: The problem of Alzheimer's disease as a clue to immortality — part 1
  35. Enhancement by caffeine of mammary gland lobulo-alveolar development in mice: a function of increased corticosteroneJ Environ Pathol Toxicol Oncol · 1994 · PMID 7884647 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  36. Coffee and serum gamma-glutamyltransferase: a study of self-defense officials in JapanAm J Epidemiol · 1994 · PMID 7909403 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  37. Unexpected effects of coffee consumption on liver enzymesEur J Epidemiol · 1993 · PMID 8104822 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  38. Acetylcholine output from the ischemic rat cerebral cortex: effects of adenosine agonistsBrain Res · 1993 · PMID 8186988 · cited in Epilepsy and Progesterone
  39. Effect of adenosine receptor agonists on spontaneous and K(+)-evoked acetylcholine release from the in vivo rat cerebral cortexBrain Res · 1993 · PMID 8481779 · cited in Epilepsy and Progesterone
  40. Caffeine promotes survival of cultured sympathetic neurons deprived of nerve growth factor through a cAMP-dependent mechanismBiochim Biophys Acta · 1992 · PMID 1336398 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones

Showing 40 of 55. Search all of them in the database →

Not affiliated with raypeat.com. This page describes Ray Peat's published articles in our own words and links to the originals. Educational content, not medical advice.

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