Ray Peat

Ray Peat on Thyroid

By OxidativeState · · 85 articles · 153 studies

Short answer: The thyroid is the center of Ray Peat's work. He wrote that low thyroid function is far more common than blood tests show, that it should be judged by temperature, pulse and symptoms, and that the active hormone T3 depends on sugar and on the liver.

What Ray Peat wrote about the thyroid

He gave the TSH test only moderate weight. Stress, illness and other factors can hold TSH down while the tissues are short of thyroid hormone. Source: TSH, temperature, pulse rate, and other indicators in hypothyroidism

He followed Broda Barnes, who used the waking body temperature as the main sign, but added the pulse. He wrote that the two together are much better than either alone. Source: TSH, temperature, pulse rate, and other indicators in hypothyroidism

He tied thyroid to sugar. The conversion of T4 to active T3 needs glucose, the liver's T3 output depends on available glucose, and T3 protects the heart by supporting glucose oxidation. Source: Glycemia, starch, and sugar in context, Glucose and sucrose for diabetes

By a thyroid supplement he meant one that contains some T3, not T4 alone. Source: Multiple Sclerosis and other hormone related brain syndromes

He linked low thyroid to high serotonin, high estrogen, high cholesterol and insomnia. Rising cholesterol with age is, in his view, partly a compensation for falling thyroid function. Source: Serotonin, depression, and aggression: The problem of brain energy, Cholesterol, longevity, intelligence, and health, Thyroid, insomnia, and the insanities: Commonalities in disease, Natural Estrogens

Thyroid hormone keeps carbon dioxide production up, which protects against water retention and the loss of sodium and magnesium. Source: Water: swelling, tension, pain, fatigue, aging

In animal experiments on learned helplessness, T3 falls during the helpless state, and giving thyroid beforehand prevents it. Source: The dark side of stress (learned helplessness)

What he suggested in practice

  • Track temperature and pulse together, not TSH alone.
  • Measure after breakfast as well as on waking.
  • Enough sugar and protein, since both are needed to make and activate the hormone.
  • Liver about once a week: he calls it a rich source of vitamins that can suppress the thyroid if eaten more often.

Where he wrote about it

This topic comes up in 85 of the articles on his site. These are the most relevant ones:

My take

Most people are hypothyroid to some degree. Cold hands, a low pulse, constipation and brain fog go together. I check pulse and temperature, and I think anyone with those signs should talk to a doctor about their thyroid.

Quick answers

How did Ray Peat test thyroid function?

With body temperature and resting pulse together, plus symptoms. He wrote that the TSH test deserves only moderate weight.

What did Ray Peat say about TSH?

That it can look normal or low in a person who is functionally hypothyroid, because stress and other factors suppress it.

What did Ray Peat mean by a thyroid supplement?

One that contains some T3, the active hormone.

153 studies Ray Peat cited on the thyroid

  1. Plasma free fatty acids, inhibitor of extrathyroidal conversion of T4 to T3 and thyroid hormone binding inhibitor in patients with various nonthyroidal illnessesEndocrinol Jpn · 1992 · PMID 1478185 · cited in TSH, temperature, pulse rate, and other indicators in hypothyroidism
  2. Serum thyrotropin in hospitalized psychiatric patients: evidence for hyperthyrotropinemia as measured by an ultrasensitive thyrotropin assayMetabolism · 1990 · PMID 2336036 · cited in Thyroid, insomnia, and the insanities: Commonalities in disease
  3. Brain cortex reverse triiodothyronine (rT3) and triiodothyronine concentrations under steady state infusions of thyroxine and rT3Endocrinology · 1987 · PMID 3830062 · cited in Thyroid: Therapies, Confusion, and Fraud
  4. [The nature of thyroid hormone receptors. Thyroxine- and triiodothyronine-binding proteins of mitochondria]Biokhimiia · 1984 · PMID 6097306 · cited in Thyroid: Therapies, Confusion, and Fraud
  5. Stimulation of sugar transport in cultured heart cells by triiodothyronine (T3) covalently bound to red blood cells and by T3 in the presence of serumEndocrinology · 1983 · PMID 6683153 · cited in Thyroid: Therapies, Confusion, and Fraud
  6. Studies on circadian variations of plasma TSH, thyroxine and triiodothyronine in manActa Endocrinol (Copenh) · 1977 · PMID 578614 · cited in Water: swelling, tension, pain, fatigue, aging
  7. Association between low serum free thyroxine concentrations and coronary artery calcification in healthy euthyroid subjectsThyroid · 2012 · PMID 22870927 · cited in Phosphate, activation, and aging
  8. Parathyroidectomy improves the quality of sleep in maintenance hemodialysis patients with severe hyperparathyroidismJ Nephrol · 2008 · PMID 18446739 · cited in Milk in context: allergies, ecology, and some myths
  9. Parathyroidectomy reduces cardiovascular events and mortality in renal hyperparathyroidismSurgery · 2007 · PMID 17981190 · cited in Milk in context: allergies, ecology, and some myths
  10. Decreased levels of ionized calcium one year after hemithyroidectomy: importance of reduced thyroid hormonesHorm Res · 2001 · PMID 11509864 · cited in Glucose and sucrose for diabetes
  11. Sudden enlargement of local recurrent thyroid tumor after recombinant human TSH administrationJ Clin Endocrinol Metab · 2001 · PMID 11701668 · cited in TSH, temperature, pulse rate, and other indicators in hypothyroidism
  12. [Epilepsy, disturbances of behavior and consciousness in presence of normal thyroxine levels: still, consider the thyroid gland]Ned Tijdschr Geneeskd · 2000 · PMID 10665296 · cited in TSH, temperature, pulse rate, and other indicators in hypothyroidism
  13. Kinetics of red blood cell T3 uptake in hypothyroidism with or without hormonal replacement, in the ratJ Endocrinol Invest · 1999 · PMID 10342358 · cited in Thyroid: Therapies, Confusion, and Fraud
  14. Novel actions of thyroid hormone: the role of triiodothyronine in cardiac transplantationThyroid · 1996 · PMID 8936684 · cited in Heart and hormones, Thyroid: Therapies, Confusion, and Fraud
  15. Influence of nonesterified fatty acids and lysolecithins on thyroxine binding to thyroxine-binding globulin and transthyretinThyroid · 1995 · PMID 7488876 · cited in Alzheimer's: The problem of Alzheimer's disease as a clue to immortality — part 2
  16. Thyroid volume in type 1 diabetes patients without overt thyroid diseaseActa Diabetol · 1995 · PMID 7612918 · cited in Diabetes, scleroderma, oils and hormones
  17. Portal-systemic encephalopathy and hypothalamic hypothyroidism: effect of thyroid hormone on ammonia metabolismIntern Med · 1993 · PMID 8312666 · cited in Fatigue, aging, and recuperation
  18. Fatty acid-induced increase in serum dialyzable free thyroxine after physical exercise: implication for nonthyroidal illnessJ Clin Endocrinol Metab · 1992 · PMID 1592881 · cited in TSH, temperature, pulse rate, and other indicators in hypothyroidism
  19. [The nature of thyroid hormone receptors. Intracellular functions of thyroxine-binding prealbumin]Biokhimiia · 1985 · PMID 2415173 · cited in Tissue-bound estrogen in aging, Thyroid: Therapies, Confusion, and Fraud
  20. Low triiodothyronine and raised reverse triiodothyronine levels in patients over fifty years of age who have type II diabetes mellitus: influence of metabolic control, not ageJ Am Geriatr Soc · 1984 · PMID 6715765 · cited in Glycemia, starch, and sugar in context
  21. [The nature of thyroid hormone receptors. Translocation of thyroid hormones through plasma membranes]Biokhimiia · 1984 · PMID 6093898 · cited in Thyroid: Therapies, Confusion, and Fraud
  22. Triiodothyronine and thyroid-stimulating hormone in protein-calorie malnutrition in infantsLancet · 1975 · PMID 53331 · cited in TSH, temperature, pulse rate, and other indicators in hypothyroidism
  23. TSH-induced release of 5-hydroxytryptamine and histamine rat thyroid mast cellsEndocrinology · 1972 · PMID 4109651 · cited in TSH, temperature, pulse rate, and other indicators in hypothyroidism
  24. TSH-induced appearance and stimulation of amine-containing mast cells in the mouse thyroidEndocrinology · 1971 · PMID 5558000 · cited in TSH, temperature, pulse rate, and other indicators in hypothyroidism
  25. Myxedema and ataxia. Cerebellar alterations and "neural myxedema bodies"Neurology · 1966 · PMID 5950589 · cited in BSE ("mad cow"), scrapie, etc.: Stimulated amyloid degeneration and the toxic fats
  26. Associations of triiodothyronine levels with carotid atherosclerosis and arterial stiffness in hemodialysis patientsClin J Am Soc Nephrol · 2011 · PMID 21836150 · cited in Phosphate, activation, and aging
  27. The bone histology spectrum in experimental renal failure: adverse effects of phosphate and parathyroid hormone disturbancesCalcif Tissue Int · 2010 · PMID 20428857 · cited in Sugar issues
  28. Low density lipoprotein-cholesterol levels affect vertebral fracture risk in female patients with primary hyperparathyroidismExp Clin Endocrinol Diabetes · 2010 · PMID 19609845 · cited in Osteoporosis, aging, tissue renewal, and product science
  29. Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and womenClin Endocrinol (Oxf) · 2009 · PMID 19250270 · cited in Milk in context: allergies, ecology, and some myths
  30. The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptorCancer Res · 2009 · PMID 19706771 · cited in Milk in context: allergies, ecology, and some myths
  31. Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional studyCardiovasc Diabetol · 2009 · PMID 19187564 · cited in Milk in context: allergies, ecology, and some myths
  32. A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosisJ Neurol Neurosurg Psychiatry · 2008 · PMID 17578859 · cited in Milk in context: allergies, ecology, and some myths
  33. Thyroid hormones and the central nervous system of mammals (Review)Mol Med Rep · 2008 · PMID 21479409 · cited in Alzheimer's: The problem of Alzheimer's disease as a clue to immortality — part 1, Alzheimer's: The problem of Alzheimer's disease as a clue to immortality — part 2
  34. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2Cell Metab · 2007 · PMID 17189204 · cited in Protective CO2 and aging
  35. Association between hypothyroidism and small intestinal bacterial overgrowthJ Clin Endocrinol Metab · 2007 · PMID 17698907 · cited in Milk in context: allergies, ecology, and some myths
  36. Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric-oxide synthaseJ Biol Chem · 2006 · PMID 16361261 · cited in The dark side of stress (learned helplessness)
  37. Peripheral triiodothyronine (T(3)) levels during escapable and inescapable footshockPhysiol Behav · 2006 · PMID 16256154 · cited in The dark side of stress (learned helplessness)
  38. Thyroid hormone targets matrix Gla protein gene associated with vascular smooth muscle calcificationCirc Res · 2005 · PMID 16100044 · cited in Phosphate, activation, and aging
  39. Parathyroid hormone and leptin--new peptides, expanding clinical prospectsExpert Opin Investig Drugs · 2005 · PMID 15833057 · cited in Osteoporosis, aging, tissue renewal, and product science
  40. Subclinical hypothyroidism may be associated with elevated high-sensitive c-reactive protein (low grade inflammation) and fasting hyperinsulinemiaEndocr J · 2005 · PMID 15758563 · cited in Cholesterol, longevity, intelligence, and health

Showing 40 of 153. Search all of them in the database →

Not affiliated with raypeat.com. This page describes Ray Peat's published articles in our own words and links to the originals. Educational content, not medical advice.

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