Ray Peat

Ray Peat on Cortisol and Stress

By OxidativeState · · 66 articles · 140 studies

Short answer: Ray Peat described cortisol as the hormone that keeps you alive by taking you apart. It rises when sugar and energy run short, breaks down muscle and thymus, and shrinks the brain. He lowered it with food, light and the protective hormones, not with willpower.

What Ray Peat wrote about cortisol

Cortisol protects cells in an emergency by blocking over-stimulation and supplying material for energy. But it can kill the cells that depend on glucose, such as nerve cells and thymus cells, leading to immune deficiency and brain damage. Source: Cataracts: water, energy, light, and aging

He pointed to Cushing's disease: too much cortisol shrinks the brain, and when the cortisol is normalized the brain size is restored. Source: The dark side of stress (learned helplessness)

Sugar is the first answer. He lists sugar as reducing cortisol, adrenaline and free fatty acids, and wrote that sugar together with fat and minerals, as in milk, is needed to lower cortisol and keep the thyroid working. Source: Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer, Multiple sclerosis, protein, fats, and progesterone

Wild monkeys have low cortisol on a fruit diet and higher cortisol when they eat less sugar. Source: Sugar issues

Eating only muscle meat mimics stress. Its tryptophan raises serotonin, and serotonin stimulates more cortisol. Source: Gelatin, stress, longevity

Gut irritation raises it through endotoxin and serotonin. Source: Serotonin: Effects in disease, aging and inflammation

Darkness raises it. So does the long night without food, until breakfast lets it fall. Source: Stem cells, cell culture, and culture: Issues in regeneration, TSH, temperature, pulse rate, and other indicators in hypothyroidism

Progesterone restrains it, by damping the ACTH stress response and limiting cortisol's harmful actions. Cortisol in turn drives estrogen production in fat. Source: Preventing and treating cancer with progesterone, Breast Cancer

A deficient thyroid leaves cortisol in excess relative to pregnenolone and progesterone. That ratio is how he defined the energy-deficient state. Source: The transparency of life: Cataracts as a model of age-related disease

What he suggested in practice

  • Sugar with minerals: milk and fruit.
  • Breakfast, and something salty and sweet before bed.
  • Gelatin with meat.
  • Light, especially in winter.
  • A daily raw carrot.
  • Vitamin B1 and niacinamide, which he lists with sugar among the things that lower stress hormones.

Where he wrote about it

This topic comes up in 66 of the articles on his site. These are the most relevant ones:

My take

The gut, muscle and brain carry the most cortisol receptors. More cortisol means less muscle, lower brain volume, slower gut motility and a weaker gut barrier. I keep it down with carbs, salt, sleep and sunlight.

Quick answers

What did Ray Peat say about cortisol?

That it is an emergency hormone which, when chronically high, breaks down muscle, thymus and brain tissue, and that it rises whenever sugar and cellular energy are short.

How did Ray Peat suggest lowering cortisol?

With enough sugar together with minerals, as in milk and fruit, with breakfast and food at bedtime, gelatin, salt, light, good thyroid function and the protective hormones progesterone and pregnenolone.

140 studies Ray Peat cited on cortisol

  1. Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stressEndocrinology · 2004 · PMID 15142987 · cited in Sugar issues
  2. The influence of aspirin on exercise-induced changes in adrenocorticotrophic hormone (ACTH), cortisol and aldosterone (ALD) concentrationsEur J Appl Physiol · 2003 · PMID 12665982 · cited in When energy fails: Edema, heart failure, hypertension, sarcopenia, etc
  3. Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female ratsEndocrinology · 1992 · PMID 1324155 · cited in Estrogen — Age Stress Hormone
  4. Stress and corticosteroid modulation of seizures and synaptic inhibition in the hippocampusExp Neurol · 2012 · PMID 22227061 · cited in When energy fails: Edema, heart failure, hypertension, sarcopenia, etc
  5. Estrogen potentiates adrenocortical responses to stress in female ratsAm J Physiol Endocrinol Metab · 2007 · PMID 17179393 · cited in Serotonin: Effects in disease, aging and inflammation
  6. A new perspective on glucocorticoid feedback: relation to stress, carbohydrate feeding and feeling betterJ Neuroendocrinol · 2001 · PMID 11578533 · cited in Glycemia, starch, and sugar in context
  7. Menstrual abnormalities in women with Cushing's disease are correlated with hypercortisolemia rather than raised circulating androgen levelsJ Clin Endocrinol Metab · 1998 · PMID 9745407 · cited in Estrogen — Age Stress Hormone
  8. [A case of concurrent bilateral adrenocortical adenoma causing Cushing's syndrome]Hinyokika Kiyo · 1997 · PMID 9161855 · cited in Estrogen — Age Stress Hormone
  9. Stimulation of neonatal mouse calvarial bone resorption by the glucocorticoids hydrocortisone and dexamethasoneJ Bone Miner Res · 1996 · PMID 8889841 · cited in Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy
  10. Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of ConfusionStress · 1996 · PMID 9807058 · cited in Estrogen — Age Stress Hormone
  11. Activation of the baboon fetal pituitary-adrenocortical axis at midgestation by estrogen: responsivity of the fetal adrenal gland to adrenocorticotropic hormone in vitroBiol Reprod · 1995 · PMID 8527531 · cited in Estrogen — Age Stress Hormone
  12. Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasiaJ Clin Endocrinol Metab · 1993 · PMID 8345057 · cited in Estrogen — Age Stress Hormone
  13. Long-term salt loading impairs pituitary responsiveness to ACTH secretagogues and stress in ratsPeptides · 1990 · PMID 2160653 · cited in Water: swelling, tension, pain, fatigue, aging
  14. Effect of stress and glucocorticoids on the gastrointestinal cholinergic enzymesArch Int Pharmacodyn Ther · 1986 · PMID 3718075 · cited in The dark side of stress (learned helplessness)
  15. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesisEndocr Rev · 1986 · PMID 3527687 · cited in Oils in Context
  16. Protective effects of aspirin from cardiac hypertrophy and oxidative stress in cardiomyopathic hamstersOxid Med Cell Longev · 2012 · PMID 22829962 · cited in The Cancer Matrix
  17. Cortisol synthesis in epidermis is induced by IL-1 and tissue injuryJ Biol Chem · 2011 · PMID 21239489 · cited in Cancer: Disorder and Energy
  18. Metabolic mechanisms of methanol/formaldehyde in isolated rat hepatocytes: carbonyl-metabolizing enzymes versus oxidative stressChem Biol Interact · 2011 · PMID 21276436 · cited in Sugar issues
  19. Estrogen promotes stress sensitivity in a prefrontal cortex-amygdala pathwayCereb Cortex · 2010 · PMID 20139149 · cited in Serotonin: Effects in disease, aging and inflammation
  20. Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal womenMenopause · 2010 · PMID 20616673 · cited in Hot flashes, energy, and aging
  21. Sources of variation in fecal cortisol levels in howler monkeys in BelizeAm J Primatol · 2010 · PMID 20166191 · cited in Sugar issues
  22. Management of corticosteroid-induced osteoporosisDrug Ther Bull · 2010 · PMID 20810708 · cited in Osteoporosis, harmful calcification, and nerve/muscle malfunctions
  23. Dietary n-3 HUFA affects mitochondrial fatty acid beta-oxidation capacity and susceptibility to oxidative stress in Atlantic salmonLipids · 2008 · PMID 18615261 · cited in Fats, functions & malfunctions
  24. Changes in regional long-term oxidative metabolism induced by partial serotonergic denervation and chronic variable stress in rat brainNeurochem Int · 2008 · PMID 17884257 · cited in Osteoporosis, aging, tissue renewal, and product science
  25. Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich dietJ Gerontol A Biol Sci Med Sci · 2007 · PMID 18000140 · cited in Cancer: Disorder and Energy
  26. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitisGastroenterology · 2007 · PMID 17681180 · cited in Osteoporosis, aging, tissue renewal, and product science
  27. Orthostatic stress response during the menstrual cycle is unaltered in formerly preeclamptic women with low plasma volumeReprod Sci · 2007 · PMID 17636218 · cited in Salt, energy, metabolic rate, and longevity
  28. Salivary cortisol and memory function in human agingNeurobiol Aging · 2006 · PMID 16274857 · cited in Stem cells, cell culture, and culture: Issues in regeneration
  29. Coenzyme Q10 protects from aging-related oxidative stress and improves mitochondrial function in heart of rats fed a polyunsaturated fatty acid (PUFA)-rich dietJ Gerontol A Biol Sci Med Sci · 2005 · PMID 16127098 · cited in Cancer: Disorder and Energy
  30. Cholesterol-producing transgenic Caenorhabditis elegans lives longer due to newly acquired enhanced stress resistanceBiochem Biophys Res Commun · 2005 · PMID 15707967 · cited in Cholesterol, longevity, intelligence, and health
  31. Enhancement of lactate metabolism in the basolateral amygdala by physical and psychological stress: role of benzodiazepine receptorsBrain Res · 2005 · PMID 16309628 · cited in Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
  32. Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stressJ Clin Pathol · 2005 · PMID 16189147 · cited in Preventing and treating cancer with progesterone
  33. Excess aldosterone under normal salt diet induces cardiac hypertrophy and infiltration via oxidative stressHypertens Res · 2005 · PMID 16156509 · cited in Water: swelling, tension, pain, fatigue, aging
  34. Preslaughter stress and muscle energy largely determine pork quality at two commercial processing plantsJ Anim Sci · 2004 · PMID 15144080 · cited in Meat physiology, stress, and degenerative physiology
  35. Regulation of steroidogenesis by p53 in macaque granulosa cells and H295R human adrenocortical cellsEndocrinology · 2004 · PMID 15331571 · cited in RU486, Cancer, Estrogen, and Progesterone
  36. Effect of stress-induced lipid peroxidation on functions of rat peritoneal macrophagesCell Biol Int · 2004 · PMID 15261159 · cited in Stem cells, cell culture, and culture: Issues in regeneration
  37. Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascadeEndocr J · 2004 · PMID 15118277 · cited in Water: swelling, tension, pain, fatigue, aging
  38. Protection of adrenocortical activity by dietary casein in ether anaesthetized ratsIndian J Exp Biol · 2003 · PMID 15255650 · cited in Milk in context: allergies, ecology, and some myths
  39. Suppression of hippocampal neurogenesis is associated with developmental stage, number of perinatal seizure episodes, and glucocorticosteroid levelExp Neurol · 2003 · PMID 14637092 · cited in Stem cells, cell culture, and culture: Issues in regeneration
  40. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and responseComp Biochem Physiol C Toxicol Pharmacol · 2002 · PMID 12458179 · cited in Serotonin: Effects in disease, aging and inflammation

Showing 40 of 140. Search all of them in the database →

Not affiliated with raypeat.com. This page describes Ray Peat's published articles in our own words and links to the originals. Educational content, not medical advice.

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