Endotoxin makes you dumb and depressed.
In this article
Injecting even a small amount of endotoxin into people, makes them depressed and lowers their cognitive function.
[PMID:11343523]
You are constantly under the assault of endotoxin.
but you can thank your gut barrier for blocking them from entering your bloodstream.
In this article I'll present the link between:
Endotoxin
and
Your mood, cognitive function, creativity and the ability to enjoy life.
Anhedonia, which is the lack in the ability to sense pleasure and motivation can be created with endotoxin.
but how can this be?
well... this study may shed some light.
In 2011, researchers gave people endotoxin from E.coli
Cortisol went thru the roof.
High CORTISOL is catabolic to the brain while lowering cognitive function.(PMID: 30355700, 26291281 ,37583892)
Not only cortisol increased, several inflammatory mediators known to drive neuroinflammation also went up.
BUT THAT'S NOT ALL
Endotoxin directly nukes your:
SOCIAL COGNITIVE PROCESSING
You are not introvert, you are probably "high" from endotoxin.
This means that once endotoxin enters your blood.
It immediately produces stress.
- Cortisol shoots up
- Inflammation skyrockets
- You lose the ability to feel joy and motivation
- Cognitive function dumps.
- Lowers your social abilities.
One of the mediators that allow endotoxin to wreak havoc are the
TLR4 receptors
Mice exposed to endotoxin had severe liver damage.
TLR4-knockout mice exposed to endotoxin did not suffer similar damage.
So many people suffer from attention deficit disorders.
The solution is usually a dopamine agonist that blocks adrenaline breakdown, which makes you stuck in a fight or flight.
(the dopamine part is not bad tho)
Instead how bout trying to solve the core issue?
Endotoxin nukes attention span and the ability to focus
The goal should be enhancing the gut barrier and improve dopamine signaling.
In this study, BPC-157 healed gut damage
you can grab some here:
BPC-157 CapsulesView productSoluble fiber feeds the bacteria and supports endotoxin production.
Insoluble fiber collects the bacteria and carries it out of the colon
Eating carrots and mushrooms as your main fiber content can be very beneficial for your microbiome and gut barrier.
The serotonin link
95% of your serotonin is produced in your gut.
It's main role should be helping smooth muscles in your colon to contract and push food faster.
But too much serotonin allows bad bacteria to communicate and form quorums.
High gut serotonin is also known to cause inflammation and diarrhea.
When the gut barrier is weak it the worse.
Serotonin enters the bloodstream and can enter the brain.
Inside the brain serotonin lowers ATP production and inhibit dopamine production, so prolactin will rise.
This is how SSRI drugs raise prolactin
6 steps to nuke endotoxin
1.Focus on simple sugar
Honey, fruits, table sugar, juices, Coke, Redbull.
those will be absorbed in the small intestine.
Most bacteria lives in the large intestine(colon), by eating easy do digest sugars you will starve the bacteria.
Stop eating salad, soluble fiber, legumes and starches if you suspect endotoxin overload.
you can make your situation much worse.
Those will feed your gram-negative bacteria and raise endotoxin production.
2.Prepare for die-offs
Once bad bacteria start dying they will release most of their endotoxin so you must enhance your gut barrier while BINDING the endotoxin.
Enhancing the barrier:
-Sugar is what forms your mucus so don't undereat it
-BPC-157 will bullet proof your barrier
-Niacinamide will also enhance your barrier
Bind the endotoxin
-Carrots and mushrooms contain a bunch of soluble fiber that brushes the bad bacteria away before reaching the barrier.
-Activated charcoal can bind the endotoxin and deactivate it
3.Speed up your digestion
-Mushrooms will speed up your digestion
-Short walk after every meal
-Thyroid hormones will raise metabolism and speed up digestion
-B1 increases cellular energy which your gut cells need to contract and move food.
4.Raise CO2
-CARBS: the most effective way to raise co2 production, this will help acidify your gut and kill the bad bacteria.
-B1 is a carbonic anhydrase inhibitor and raises cellular energy production which is the main source for CO2.
-Calcium is another great mineral that activates oxidative state and push CO2 production while helping the gut function.
-Baking soda
-Aspirin
5.Lower Serotonin
-Salt is needed to secrete serotonin out
-Potassium is also crucial for deactivating serotonin.
-Cyproheptadine is very effective compound for inhibiting serotonin and even histamine.
-Ondansetron is another serotonin antagonist, but it can slow gut motility so cypro is probably better.
-Aspirin
6. Restore Dopamine signaling
-Sugar is the most important factor here, it's the main fuel of your neurons
-Lowering serotonin is crucial for this step
-Tyrosine: is the building block for dopamine, supplement it can be very effective for raising dopamine production
-sun exposure is VERY crucial for signaling dopamine production, especially looking outside at the sky, sun, trees forces your brain to increase dopamine production.
-Bromantane will upregulates the enzymes that produce dopamine thus raising its levels.
-BPC 157 also shown to restore dopamine signaling, even after amphetamines abuse.
BPC-157 CapsulesView product-Meditation is very effective in stimulating the parasympathetic system which crucial for dopamine production.
-Avoid doomscrolling, it will mess up your whole dopaminergic system.
7. Eat organs and seafood
Beef liver, heart and oysters are super foods.
They contain so many vitamins and minerals which are crucial for restoring the gut barrier, cellular energy and gut motility.
8. Red light and sun
As an organisms on this planet we need light to function.
Blue light messes up everything.
Sun light and red light from chicken lamps directly on your skin and belly is how to heal yourself, boost dopamine, ATP and CO2.
If you follow those guidelines, you can begin healing and lose those endotoxins and enhance your cognitive function.
If you want a customized strategy for your specific situation, apply here.
oxidativestate.com/coaching
Hope you'll find this information useful.
Not a medical advice.
Oxidative State.