Once a brain cell dies, generating a new one in its place is extremely difficult, Neurological disorders like…

Once a brain cell dies, generating a new one in its place is extremely difficult, Neurological disorders like Alzheimer's are characterized by accelerated brain cell loss. This research demonstrates that vitamin B1 prevents the death of brain cells, thus might an effective tool against neurodegeneration.
They gave the rats equivalent to a 160mg supplementation in humans.

B1 improved insulin signaling.

Streptozotocin (STZ) is a common drug for Alzheimer's Disease, shown to alter thiamine uptake by cells.

B1 can protect from some of the damages caused by STZ.

B1 protects from hypothalamic apoptosis.

The study
- Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in ratsLife Sci · 2022 · PMID 35907494