Low B1 levels cause oxidative stress and drive neurodegeneration.
Low B1 levels cause oxidative stress and drive neurodegeneration.
main example is Alzheimer's disease.
Lack of thiamine-dependent enzymes in brain such as
-Pyruvate Dehydrogenase (PDH)
-a Ketoglutarate Dehydrogenase Complex (a-KGDH)
-Transketolase (TK)
are directly linked to AD, seen by reduced glucose metabolism.
B1 acts as an antioxidant by being a strong protector against oxidative stress.
The ability to utilize glucose is low in AD patients, this explains how B1 can treat it and lack of it can cause it.
B1 + Acetazolamide can treat parkinson
The study
- Interactions of oxidative stress with thiamine homeostasis promote neurodegenerationNeurochem Int · 2002 · PMID 11850106