Cortisol causes a significant muscle mass loss.

Cortisol causes a significant muscle mass loss.
Found to also be catabolic to the Thymus ,Heart, Liver and spleen, basically toxic to every part of our body.

Vitamin D3 on the other hand is protective against cortisol, Completely blocked the atrophy of skeletal muscle mass, Thymus ,Heart ,Liver and spleen.

dexamethasone (DEX) is a nasty synthetic glucocorticoid, God knows why but it's a standard protocol to be given to patients with inflammation, edema, certain cancers, autoimmune conditions, allergic reactions, asthma and COVD. Although that it was shown in multiple studies to suppress immunity, cause bone loss, atrophy of basically every tissue that contain amino acids.

It comes with no surprise because Cortisol main rule is to maintain Blood Glucose levels during stress and it does so by tearing apart every tissue that contains amino-acid e.g., your brain, muscle, thymus etc.

The hero of this study was Vitamin D3, We get it Easily from Cholesterol when we expose our skin to the sun, It completely blocked the nasty effects of DEX.
"Vitamin D is considered to be a potent anti-catabolic compound [1,2].
Numerous studies suggest a positive role of vitamin D in sarcopenia prevention"

Bad news for the Ice bath lovers, this study also showed that ice bath increase cortisol levels, extreme cold is a stressor so it will trigger cortisol.
"As was expected, cold water immersion caused a significant induction of hypothalamic–pituitary–adrenal (HPA) axis activation and a cortisol surge into the blood"

Main study
PMID: 33799389
PMCID: PMC7998166
DOI: 10.3390/nu13030936

1.PMID: 32699341
2.PMID: 30529188

#vitaminD#cortisol#muscle#liverhealth#bioenergetics