Tadalafil is associated with increased testosterone/estradiol ration, which also means higher DHT levels…

Tadalafil is associated with increased testosterone/estradiol ration, which also means higher DHT levels, this study proposes a mechanism.

"the exposure of osteoblasts to different concentrations of taadalafil down-regulated aromatase mRNA expression in a concentration dependent manner"

this is kinda cool, tadalafil may strengthen bone in people with estrogen dominance, as estrogen known to lower metabolic rate and osteoblasts production, while raising prolactin and the Parathyroid hormone which increase bone destruction.

the first 24h after exposure, testosterone levels rose a lot, then went down at 48h.