He CURED his depression with sun exposure.
Most depressed people sit in their office most days, they barely look outside and focus on blue screens. Sunlight activates our metabolism, wakes up thousands of genes responsible for mood, cognitive function, strength. The part of the eye that is responsible for converting photons to electric signals (aka retina) ,Has 3-5 times more mitochondria than an average cell. The sun has an insane range of infrared red light which activates energy production in our retina. DOPAMINE production and supply to the brain relies heavily on retinal energy production and sun exposure.
Prolactin & dopamine studies
11 posts on prolactin and dopamine. Every post breaks down a real PubMed study and links to the paper.
He CURED his depression with sun exposure.
Most depressed people sit in their office most days, they barely look outside and focus on blue screens. Sunlight activates our metabolism, wakes up thousands of genes responsible for mood, cognitive function, strength. The part of the eye that is responsible for converting photons to electric signals (aka retina) ,Has 3-5 times more mitochondria than an average cell. The sun has an insane range of infrared red light which activates energy production in our retina. DOPAMINE production and supply to the brain relies heavily on retinal energy production and sun exposure.
He SOLVED his adderall addiction with BPC-157.
Too many people abuse amphetamine without addressing the root cause of their ADHD. Adderall doesn't give you dopamine. It BORROWS it. That's why the same dose that used to give you laser focus now barely gets you out of bed. Here's the part almost nobody talks about: your dopamine system isn't broken permanently. It's suppressed, and with the right strategy it can be reversed, full article below.
Neurons don't touch. Between every single one of them is a tiny gap, they communicate with electrical signals…
Dopamine is one of those messengers. It's behind why you want things, why you chase things, why achieving something feels good. Every ounce of motivation you've ever felt started dopamine.
Russian smart drugs are kinda crazy.
Bromantane increases the expression of genes responsible for producing Tyrosine hydrolase which is the first and rate limiting enzyme in dopamine synthesis and DOPA decarboxylase which removes the carboxyl group from L-DOPA and yields dopamine. Bromantane enhances cognitive function, increase motivation while lowering prolactin and serotonin. "This leads to a conclusion that the pharmacological activity of Ladasten is related to activation of de novo synthesis of TH and DDC".
SSRIs cause sexual dysfunction.
Lowering serotonin,histamine and prolactin can fix that. In this study, 7 males who developed sexual dysfunction following treatment with SSRIs took cyproheptadine (4-12 mg) 1-2 h before sexual activity. 5/7 patients had improvement in sexual function.
Consuming enough salt is crucial for keeping prolactin levels in check.
Tadalafil is associated with increased testosterone/estradiol ration, which also means higher DHT levels…
Having kids lowers prolactin levels in women, that's kinda cool
Low sodium intake increases prolactin
A systematic review on the role of aromatase inhibitors for men with prolactinoma and hypogonadism shows that…
A combination of Androgen(DHT/T) + Aromatase inhibitor(Examastane) + Dopamine agonist(Bromocriptine) can be VERY powerful in lowering prolactin and estrogen. "In 2002, Gillam and colleagues reported on a case of a 34-year-old male patient with a macroprolactinoma and low testosterone levels; the patient responded to cabergoline treatment with significant reduction in prolactin levels, from 10,362 μf/L to 61 μg/L. However, as symptoms of hypogonadism persisted, testosterone was added, followed by an increase in prolactin levels, which came back down following the discontinuation of testosterone. A combination of cabergoline with anastrozole (1 mg daily) and a testosterone treatment resulted in improved clinical symptoms without increasing prolactin levels. Interestingly, at attempt to discontinue the anastrozole to determine the effect of anastrozole on prolactin levels resulted in an immediate spike in the prolactin levels, with a subsequent decline after re-introducing the aromatase inhibitor. The authors concluded that the addition of an aromatase inhibitor allowed for the continued use of testosterone as it prevented the testosterone-induced prolactin increase and potential tumor enlargement. Furthermore, the combination of an aromatase inhibitor with a dopamine agonist resulted in prolactin levels that were lower than those recorded at any other time point," "Lima and colleagues reported on a 29-year-old man with hyperprolactinemia exacerbated by testosterone replacement therapy. The patient was diagnosed with a giant prolactinoma and achieved normal serum prolactin levels with cabergoline. However, as symptoms of hypogonadism persisted, testosterone replacement therapy was initiated, followed by a more than six-fold increase in prolactin levels. Adding letrozole (2.5 mg daily) treatment was associated with a significant reduction in prolactin levels " A much better option than testosterone would be DHT, which can't be aromatised to estrogen, also exemestane was shown to be much safer in blocking aromatase, this shows that combination of Androgen + Aromatase inhibitor + Dopamine agonist can be VERY powerful in lowering prolactin and estrogen. [PMID: 36835974]
Direct sunlight is crucial for Dopamine synthesis.
A THREAD 🧵
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