72 patients with diarrhea-dominant irritable bowel syndrome enrolled in a study to see if supplementing…

72 patients with diarrhea-dominant irritable bowel syndrome enrolled in a study to see if supplementing S.Boulardii for 6 weeks can lower inflammation.
The results?
Cytokine levels in blood and colonic mucosa dropped a lot, TNF-a which is a major inflammatory biomarker fell drastically.

Quality of life improved in the S.Boulardii group.

The study
- Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trialEur J Gastroenterol Hepatol · 2014 · PMID 24722560