Ray Peat

Ray Peat on Alcohol

By OxidativeState · · 37 articles · 30 studies

Short answer: Ray Peat's website articles say little about drinking itself. Where alcohol appears, he treats it as a substance that pushes the cell toward a reduced, low-energy state, and he argues that the damage it does to the liver depends on the fat in the diet.

What Ray Peat wrote about alcohol

He described ethyl alcohol as a common, potentially toxic substance that lets an excess of electrons build up in the cell, moving it away from the stable oxidized state. Source: Sugar issues

He wrote that fructose speeds up the oxidation of alcohol, by about 80% in the research he cites, and prevents the oxidative damage by restoring the cell's redox balance. Source: Sugar issues

He cites the work of Nanji's group, in which saturated fats reversed the inflammation, cell death and scarring of alcoholic liver disease even while alcohol was continued, and fish oil and other unsaturated fats made it worse. Source: Fats, functions & malfunctions

In his list of the harms of polyunsaturated fats he states that they are required for alcoholic liver cirrhosis to develop. Source: Membranes, plasma membranes, and surfaces

Glycine protects against fat accumulation in alcohol-induced liver injury, which he took as a reason to add gelatin. Source: Fats, functions & malfunctions

He cites studies in which coffee drinkers who also drank alcohol had healthier liver enzyme levels and less cirrhosis. Source: Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones

What he suggested in practice

  • Saturated fat instead of unsaturated fat.
  • Sugar or fruit, gelatin and coffee.
  • None of this makes heavy drinking safe.

Where he wrote about it

This topic comes up in 37 of the articles on his site. These are the most relevant ones:

Quick answers

What did Ray Peat say about alcohol?

That it shifts cells toward a reduced, low-energy state, and that the liver damage linked to alcohol depends heavily on polyunsaturated fat in the diet. His articles do not give advice on how much to drink.

What protects the liver from alcohol, according to Ray Peat?

He cites studies on saturated fats, glycine, fructose and coffee, and on the harm added by fish oil and other unsaturated fats.

30 studies Ray Peat cited on alcohol

  1. Dietary factors and alcoholic cirrhosisAlcohol Clin Exp Res · 1986 · PMID 3526949 · cited in Fats and degeneration
  2. Metabolic mechanisms of methanol/formaldehyde in isolated rat hepatocytes: carbonyl-metabolizing enzymes versus oxidative stressChem Biol Interact · 2011 · PMID 21276436 · cited in Sugar issues
  3. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitisGastroenterology · 2007 · PMID 17681180 · cited in Osteoporosis, aging, tissue renewal, and product science
  4. Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosisBr J Pharmacol · 2006 · PMID 16783407 · cited in Rosacea, inflammation, and aging: The inefficiency of stress
  5. Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acidsAm J Clin Nutr · 2004 · PMID 14684412 · cited in Osteoporosis, aging, tissue renewal, and product science
  6. Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administrationJ Pharmacol Exp Ther · 2001 · PMID 11602676 · cited in Fats, functions & malfunctions, Fats and degeneration
  7. Moderate levels of ethanol induce expression of vascular endothelial growth factor and stimulate angiogenesisAm J Physiol Regul Integr Comp Physiol · 2001 · PMID 11404314 · cited in Estrogen, progesterone, and cancer: Conflicts of interest in regulation and product promotion
  8. Estrogen is involved in early alcohol-induced liver injury in a rat enteral feeding modelHepatology · 2000 · PMID 10613736 · cited in Estrogen and Osteoporosis
  9. Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkersInt J Epidemiol · 1998 · PMID 9698132 · cited in Caffeine: A vitamin-like nutrient, or adaptogen. Questions about tea and coffee, cancer and other degenerative diseases, and the hormones
  10. Increased circulating products of lipid peroxidation in patients with alcoholic liver diseaseAlcohol Clin Exp Res · 1998 · PMID 9514306 · cited in Fats and degeneration
  11. Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the ratHepatology · 1997 · PMID 9397995 · cited in Rosacea, inflammation, and aging: The inefficiency of stress, Estrogen and Osteoporosis
  12. Hepatocellular carcinoma and hepatic cirrhosis in Mexico: a 25 year necroscopy reviewHepatogastroenterology · 1997 · PMID 9356862 · cited in Food-junk and some mystery ailments: Fatigue, Alzheimer's, Colitis, Immunodeficiency
  13. Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver diseaseJ Pharmacol Exp Ther · 1996 · PMID 8667240 · cited in Fats and degeneration
  14. The phytoestrogen congeners of alcoholic beverages: current statusProc Soc Exp Biol Med · 1995 · PMID 7892304 · cited in Estriol, DES, DDT, etc
  15. Dietary saturated fatty acids: a novel treatment for alcoholic liver diseaseGastroenterology · 1995 · PMID 7615205 · cited in Fats and degeneration
  16. Aspirin dose-dependently reduces alcohol-induced birth defects and prostaglandin E levels in miceTeratology · 1991 · PMID 1771594 · cited in Eclampsia in the Real Organism: A Paradigm of General Distress Applicable in Infants, Adults, Etc
  17. Lipoproteins secreted by cultured rat hepatocytes contain the antioxidant 1-alk-1-enyl-2-acylglycerophosphoethanolamineBiochim Biophys Acta · 1990 · PMID 2116174 · cited in Fats, functions & malfunctions
  18. Dietary linoleic acid is required for development of experimentally induced alcoholic liver injuryLife Sci · 1989 · PMID 2915600 · cited in Oils in Context, Unsaturated Vegetable Oils: Toxic
  19. Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistanceJ Clin Invest · 1988 · PMID 3280601 · cited in Sugar issues
  20. [Trends of mortality from cirrhosis in France between 1925 and 1982]Gastroenterol Clin Biol · 1986 · PMID 3758591 · cited in Food-junk and some mystery ailments: Fatigue, Alzheimer's, Colitis, Immunodeficiency
  21. [Fibrosis and cirrhosis in the rabbit induced by diethylstilbestrol and its inhibition with progesterone]Medicina (B Aires) · 1985 · PMID 3841921 · cited in Rosacea, inflammation, and aging: The inefficiency of stress
  22. Turnover rates of the molecular species of ethanolamine plasmalogen of rat brainJ Neurochem · 1984 · PMID 6699646 · cited in Fats, functions & malfunctions
  23. Hepatocellular carcinoma and cirrhosis: a review of their relative incidence in a 25-year period in the Florence areaHepatogastroenterology · 1984 · PMID 6096240 · cited in Food-junk and some mystery ailments: Fatigue, Alzheimer's, Colitis, Immunodeficiency
  24. Primary hepatic cancer and liver cirrhosis. Autopsy study covering fifty yearsHepatogastroenterology · 1984 · PMID 6096239 · cited in Food-junk and some mystery ailments: Fatigue, Alzheimer's, Colitis, Immunodeficiency
  25. Unsuspected benzyl alcohol hypersensitivityN Engl J Med · 1982 · PMID 7053477 · cited in Progesterone Deceptions
  26. Hepatocellular carcinoma and hepatic cirrhosis in the west of Scotland: a 25-year necropsy reviewJ Clin Pathol · 1978 · PMID 204664 · cited in Food-junk and some mystery ailments: Fatigue, Alzheimer's, Colitis, Immunodeficiency
  27. Plasma prolactin and prolactin release in liver cirrhosisActa Hepatogastroenterol (Stuttg) · 1977 · PMID 404818 · cited in Food-junk and some mystery ailments: Fatigue, Alzheimer's, Colitis, Immunodeficiency
  28. Parenteral toxicity studies with benzyl alcoholToxicol Appl Pharmacol · 1971 · PMID 5542834 · cited in Progesterone Deceptions
  29. The influence of fructose and its metabolites on ethanol metabolism in vitroBiochem J · 1967 · PMID 4291557 · cited in Sugar issues
  30. [The aldosterone-antagonistic effect of progesterone. A preliminary note on the effects of progesterone on 2 patients with liver cirrhosis]Ugeskr Laeger · 1960 · PMID 14400966 · cited in When energy fails: Edema, heart failure, hypertension, sarcopenia, etc

Open these in the database →

Not affiliated with raypeat.com. This page describes Ray Peat's published articles in our own words and links to the originals. Educational content, not medical advice.

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