Ray Peat

Ray Peat on Magnesium

By OxidativeState · · 37 articles · 23 studies

Short answer: Ray Peat tied magnesium to the thyroid. He wrote that cells hold magnesium only when they have energy, so a hypothyroid person loses it under stress, and that magnesium deficiency causes inflammation, cramps and soft tissue calcification.

What Ray Peat wrote about magnesium

Much of the magnesium inside a cell is bound to ATP. When stress drains the cell's energy in a hypothyroid state, the cell loses its magnesium. Source: Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy, Diabetes, scleroderma, oils and hormones

T3 directly promotes the uptake of magnesium by cells. To make cells absorb and keep it, he wrote, we can increase our thyroid function. Source: Eclampsia in the Real Organism: A Paradigm of General Distress Applicable in Infants, Adults, Etc, Diabetes, scleroderma, oils and hormones

Thyroid hormone, by keeping carbon dioxide production up, protects against the loss of sodium and magnesium. Source: Water: swelling, tension, pain, fatigue, aging

Magnesium deficiency causes inflammation. His article on calcium says that people with calcium deposits cannot improve until both their calcium and magnesium intakes are adequate. Source: Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy

Magnesium is the relaxation partner of calcium in muscle, and it protects cells against calcium overload. He notes that calcium seems to help cramps by making magnesium more available. Source: Osteoporosis, harmful calcification, and nerve/muscle malfunctions, Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy, Diabetes, scleroderma, oils and hormones

It is a component of newly formed bone, and he cites magnesium therapy that prevented fractures and raised bone density. Source: Osteoporosis, harmful calcification, and nerve/muscle malfunctions

Magnesium protects against iron-driven lipid peroxidation. Source: Alzheimer's: The problem of Alzheimer's disease as a clue to immortality — part 2

Fructose improves magnesium retention, a finding he used against the anti-sugar literature. Source: Sugar issues

What he suggested in practice

  • Food sources he names: meats, fruits, leaves and coffee.
  • Fix thyroid function, or the magnesium will not stay in the cells.
  • Sodium and magnesium supplements were among the things he found helpful for premenstrual syndrome.

Where he wrote about it

This topic comes up in 37 of the articles on his site. These are the most relevant ones:

My take

I take magnesium glycinate at night, 300 to 400 mg. In the studies I have covered, magnesium improved sleep and lowered cortisol.

Quick answers

What did Ray Peat say about magnesium?

That cells need thyroid hormone and energy to retain it, that deficiency causes inflammation and cramps, and that it works with calcium to protect bone and soft tissue.

Which magnesium sources did Ray Peat mention?

Meats, fruits, leaves and coffee as foods. For eclampsia he mentions the traditional use of injected magnesium sulfate.

23 studies Ray Peat cited on magnesium

  1. Serum ionized magnesium and calcium in women after menopause: inverse relation of estrogen with ionized magnesiumFertil Steril · 1999 · PMID 10231048 · cited in Estrogen and Osteoporosis
  2. Magnesium deficiency: does it have a role to play in cataractogenesis?Exp Eye Res · 2012 · PMID 22668657 · cited in Cataracts: water, energy, light, and aging
  3. The interaction between dietary fructose and magnesium adversely affects macromineral homeostasis in menJ Am Coll Nutr · 2000 · PMID 10682873 · cited in Sugar issues
  4. Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery diseaseAm Heart J · 2000 · PMID 10925332 · cited in Multiple sclerosis, protein, fats, and progesterone
  5. Magnesium deficiency-induced osteoporosis in the rat: uncoupling of bone formation and bone resorptionMagnes Res · 1999 · PMID 10612083 · cited in Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy
  6. Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasisLife Sci · 1998 · PMID 9820125 · cited in Immunodeficiency, dioxins, stress, and the hormones
  7. Early morphological and immunological alterations in the spleen during magnesium deficiency in the ratMagnes Res · 1998 · PMID 9800684 · cited in Immunodeficiency, dioxins, stress, and the hormones
  8. Serum magnesium concentration and PTH levels. Is long-term chronic hypermagnesemia a risk factor for adynamic bone disease?Scand J Urol Nephrol · 1997 · PMID 9249893 · cited in Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy
  9. Effects of magnesium and iron on lipid peroxidation in cultured hepatocytesMol Cell Biochem · 1995 · PMID 7623785 · cited in Alzheimer's: The problem of Alzheimer's disease as a clue to immortality — part 2
  10. Effects of insulin on plasma magnesium in noninsulin-dependent diabetes mellitus: evidence for insulin resistanceJ Clin Endocrinol Metab · 1995 · PMID 7714113 · cited in Diabetes, scleroderma, oils and hormones
  11. Extracellular and intracellular magnesium depletion in pregnancy and gestational diabetesAm J Obstet Gynecol · 1995 · PMID 7892840 · cited in Diabetes, scleroderma, oils and hormones
  12. Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities StudyJ Clin Epidemiol · 1995 · PMID 7782801 · cited in Diabetes, scleroderma, oils and hormones
  13. Magnesium supplementation and osteoporosisNutr Rev · 1995 · PMID 7770187 · cited in Osteoporosis, harmful calcification, and nerve/muscle malfunctions
  14. Iron, magnesium and ischaemic heart diseaseProc Nutr Soc · 1994 · PMID 7886058 · cited in Iron's Dangers
  15. A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapyJ Reprod Med · 1990 · PMID 2352244 · cited in Estrogen and Osteoporosis
  16. Dietary fructose or starch: effects on copper, zinc, iron, manganese, calcium, and magnesium balances in humansAm J Clin Nutr · 1989 · PMID 2729168 · cited in Sugar issues
  17. Magnesium protects against neurological deficit after brain injuryBrain Res · 1989 · PMID 2784989 · cited in Estrogen — Age Stress Hormone
  18. Circadian rhythm with acrophase at night for urinary excretion of calcium and magnesium in childhood: population-based data of the cimitile study in southern ItalyMiner Electrolyte Metab · 1988 · PMID 3211091 · cited in Osteoporosis, aging, tissue renewal, and product science
  19. Effect of high calcium diet on magnesium, catecholamines, and blood pressure of stroke-prone spontaneously hypertensive ratsProc Soc Exp Biol Med · 1988 · PMID 3353396 · cited in Osteoporosis, aging, tissue renewal, and product science
  20. [Effect of sodium salicylate on renal handling of calcium, phosphate and magnesium]Nihon Yakurigaku Zasshi · 1986 · PMID 3817655 · cited in Phosphate, activation, and aging
  21. Auto-immune complications of D-penicillamine--a possible result of zinc and magnesium depletion and of pyridoxine inactivationJ Am Coll Nutr · 1982 · PMID 7185852 · cited in Immunodeficiency, dioxins, stress, and the hormones
  22. Characteristic molar ratios of magnesium, carbon dioxide, calcium and phosphorus in the mineralizing fracture callus and predentineCalcif Tissue Int · 1980 · PMID 6775794 · cited in Osteoporosis, harmful calcification, and nerve/muscle malfunctions
  23. Effect of thyroid state on magnesium concentration of rat tissuesAm J Vet Res · 1978 · PMID 629439 · cited in Water: swelling, tension, pain, fatigue, aging

Open these in the database →

Not affiliated with raypeat.com. This page describes Ray Peat's published articles in our own words and links to the originals. Educational content, not medical advice.

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